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Endocrine & Metabolic Pharmacology
Endocrinology


 MOST VIEWED PAPERS | Metabolic & Endocrine Science | calculated on 7 January 2009
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1
Exceptional
F1000 Factor 9.0

Confirmation
New Finding
Novel Drug Target
 A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection.
Pollin TI, Damcott CM, …, O'Connell JR, Shuldiner AR
Science 2008 Dec 12 322(5908):1702-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Henry Ginsberg
Evaluated 2 Jan 2009
 
2
Exceptional
F1000 Factor 8.0

Hypothesis
New Finding
Tech Advance
Novel Drug Target
 Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.
Louvet C, Szot GL, …, Weiss A, Bluestone JA
Proc Natl Acad Sci U S A 2008 Dec 2 105(48):18895-900 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steven A. Rosenzweig / Daniel Flynn
First evaluation 8 Dec 2008 | Latest evaluation 12 Dec 2008
 
3
Exceptional
F1000 Factor 10.3

Hypothesis
New Finding
Tech Advance
Novel Drug Target
 Innate immunity and intestinal microbiota in the development of Type 1 diabetes.
Wen L, Ley RE, …, Gordon JI, Chervonsky AV
Nature 2008 Oct 23 455(7216):1109-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mauro Teixeira / David Serreze / Antony Basten with Pablo Silveira / Torben Lund / Peter Van Endert / Aniko Naray-Fejes-Toth
First evaluation 3 Oct 2008 | Latest evaluation 29 Oct 2008

 
4
Exceptional
F1000 Factor 9.0

New Finding
 N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake.
Gillum MP, Zhang D, …, Cline GW, Shulman GI
Cell 2008 Nov 28 135(5):813-24 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Moore
Evaluated 12 Dec 2008
 
5
Exceptional
F1000 Factor 10.6

Confirmation
Hypothesis
New Finding
Tech Advance
Controversial
Novel Drug Target
 In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.
Zhou Q, Brown J, …, Rajagopal J, Melton DA
Nature 2008 Oct 2 455(7213):627-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anthony Means / Phillip Newmark / John Mullins with L Mullins / Raghavendra Mirmira / Ray Rodgers / Ivana Novak / Ulf Pettersson
First evaluation 4 Sep 2008 | Latest evaluation 9 Dec 2008

 
6
Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
 A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.
Liu Y, Dentin R, …, Guarente L, Montminy M
Nature 2008 Oct 5 [abstract on PubMed] [related articles] [full text]
Selected by | Fredric Wondisford
Evaluated 6 Nov 2008
 
7
Exceptional
F1000 Factor 10.4

Confirmation
Hypothesis
New Finding
Controversial
Novel Drug Target
 AMPK and PPARdelta agonists are exercise mimetics.
Narkar VA, Downes M, …, Shaw RJ, Evans RM
Cell 2008 Aug 8 134(3):405-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anthony Means / James Timmons / Fredric Wondisford / Markus Ruegg / David Mangelsdorf with Klementina Fon Tacer / Charles Brenner with Katrina L Bogan
First evaluation 12 Aug 2008 | Latest evaluation 30 Oct 2008

 
8
Exceptional
F1000 Factor 9.0

New Finding
Tech Advance
 Structure of the intact PPAR-gamma-RXR-alpha nuclear receptor complex on DNA.
Chandra V, Huang P, …, Burris TP, Rastinejad F
Nature 2008 Oct 29 350-356 [abstract on PubMed] [related articles] [full text]
Selected by | Paul Webb
Evaluated 26 Nov 2008
 
9
Recommended
F1000 Factor 3.0

New Finding
 Thyroid hormone receptor orthologues from invertebrate species with emphasis on Schistosoma mansoni.
Wu W, Niles EG, LoVerde PT
BMC Evol Biol 2007 7:150 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Webb
Evaluated 5 Oct 2007
 
10
Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappa B dependent inflammatory genes: Relevance to diabetes and inflammation.
Li Y, Reddy MA, …, Ren B, Natarajan R
J Biol Chem 2008 Jul 23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Raghavendra Mirmira
Evaluated 4 Sep 2008

Most Viewed lists are generated every day and reflect use of F1000 Biology over the preceding 14 day period.

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