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 MOST VIEWED PAPERS | Pharmacology & Drug Discovery | calculated on 2 December 2008
 browse faculty | show Most Viewed Papers in

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1
Must Read
F1000 Factor 6.4

New Finding
Tech Advance
Novel Drug Target
 Chemical control of protein stability and function in living mice.
Banaszynski LA, Sellmyer MA, …, Wandless TJ, Thorne SH
Nat Med 2008 Oct 14(10):1123-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine with Yongqiang Feng / Thomas W. von Geldern
First evaluation 20 Nov 2008 | Latest evaluation 21 Nov 2008
 
2
Must Read
F1000 Factor 6.0

New Finding
 Bioactive contaminants leach from disposable laboratory plasticware.
McDonald GR, Hudson AL, …, Edmondson DE, Holt A
Science 2008 Nov 7 322(5903):917 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 21 Nov 2008
 
3
Must Read
F1000 Factor 6.0

Hypothesis
 Predicting molecules--more realism, please!
Hoffmann R, Schleyer PR, Schaefer HF
Angew Chem Int Ed Engl 2008 47(38):7164-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 20 Nov 2008
 
4
Exceptional
F1000 Factor 9.0

New Finding
Novel Drug Target
 Deconstructing voltage sensor function and pharmacology in sodium channels.
Bosmans F, Martin-Eauclaire MF, Swartz KJ
Nature 2008 Nov 13 456(7219):202-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 26 Nov 2008
 
5
Must Read
F1000 Factor 6.8

Confirmation
Hypothesis
New Finding
Controversial
 CTLA-4 control over Foxp3+ regulatory T cell function.
Wing K, Onishi Y, …, Nomura T, Sakaguchi S
Science 2008 Oct 10 322(5899):271-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Richard Williams / Kenneth Tung with Alberta Paul / Jay Berzofsky / Arthur Hurwitz / Kendall Smith
First evaluation 22 Oct 2008 | Latest evaluation 20 Nov 2008

 
6
Exceptional
F1000 Factor 9.0

New Finding
Controversial
Refutation
 Increased cognitive functioning in symptomatic Huntington's disease as revealed by behavioral and event-related potential indices of auditory sensory memory and attention.
Beste C, Saft C, Güntürkün O, Falkenstein M
J Neurosci 2008 Nov 5 28(45):11695-702 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jerry Buccafusco
Evaluated 12 Nov 2008
 
7
Exceptional
F1000 Factor 10.3

Confirmation
Hypothesis
New Finding
Controversial
Novel Drug Target
 In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.
Zhou Q, Brown J, …, Rajagopal J, Melton DA
Nature 2008 Oct 2 455(7213):627-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anthony Means / Phillip Newmark / John Mullins with L Mullins / Raghavendra Mirmira / Ray Rodgers / Ivana Novak
First evaluation 4 Sep 2008 | Latest evaluation 29 Oct 2008

 
8
Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Anatomical profiling of G protein-coupled receptor expression.
Regard JB, Sato IT, Coughlin SR
Cell 2008 Oct 31 135(3):561-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Soeren Sheikh
Evaluated 14 Nov 2008
 
9
Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice.
Krohn R, Raffetseder U, …, Mertens PR, Weber C
Circulation 2007 Oct 16 116(16):1812-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Harrison with Klaudia Budzyn
Evaluated 20 May 2008
 
10
Exceptional
F1000 Factor 10.4

Confirmation
Hypothesis
New Finding
Controversial
Novel Drug Target
 AMPK and PPARdelta agonists are exercise mimetics.
Narkar VA, Downes M, …, Shaw RJ, Evans RM
Cell 2008 Aug 8 134(3):405-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anthony Means / James Timmons / Fredric Wondisford / Markus Ruegg / David Mangelsdorf with Klementina Fon Tacer / Charles Brenner with Katrina L Bogan
First evaluation 12 Aug 2008 | Latest evaluation 30 Oct 2008


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