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Biomacromolecule-Ligand Interactions
Cell Signalling & Trafficking Structures
Experimental Biophysical Methods
Macromolecular Assemblies & Machines
Membrane Proteins & Energy Transduction
Protein Folding
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Structure: RNA
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Biocatalysis
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 MOST VIEWED PAPERS | Structural Biology | calculated on 7 January 2009
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1
Exceptional
F1000 Factor 9.0

Controversial
 Protein dynamical transition does not require protein structure.
He Y, Ku PI, …, Chen JY, Markelz AG
Phys Rev Lett 2008 Oct 24 101(17):178103 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Gruebele with Dr. Simon Ebbinghaus
Evaluated 22 Dec 2008
 
2
Must Read
F1000 Factor 6.4

Confirmation
New Finding
Tech Advance
 Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax.
Lovell JF, Billen LP, …, Leber B, Andrews DW
Cell 2008 Dec 12 135(6):1074-84 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Colman with W. Douglas Fairlie / Douglas Green with Jerry E. Chipuk
First evaluation 19 Dec 2008 | Latest evaluation 23 Dec 2008
 
3
Recommended
F1000 Factor 3.0

Tech Advance
 The better tag remains unseen.
Durst FG, Ou HD, …, Dötsch V, Straub WE
J Am Chem Soc 2008 Nov 12 130(45):14932-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Ball with Victoria A. Higman
Evaluated 5 Dec 2008
 
4
Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Tech Advance
 PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.
Singh R, Manjunatha U, …, Jiricek J, Barry CE
Science 2008 Nov 28 322(5906):1392-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Barry Stoddard
Evaluated 2 Jan 2009
 
5
Exceptional
F1000 Factor 10.7

Hypothesis
New Finding
Controversial
 Species-specific transcription in mice carrying human chromosome 21.
Wilson MD, Barbosa-Morais NL, …, Tavaré S, Odom DT
Science 2008 Oct 17 322(5900):434-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yoav Gilad / Kenneth Zaret / Deyou Zheng / Julin Maloof with Jose M. Jimenez-Gomez / Lin Chen with Reza Kalhor / Tom Misteli with Evi Soutoglou / Heng Zhu
First evaluation 13 Oct 2008 | Latest evaluation 23 Dec 2008
 
6
Exceptional
F1000 Factor 8.0

Hypothesis
New Finding
Tech Advance
 Bleach activates a redox-regulated chaperone by oxidative protein unfolding.
Winter J, Ilbert M, …, Ozcelik D, Jakob U
Cell 2008 Nov 14 135(4):691-701 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philip Burcham / Bruce Demple
Evaluated 8 Dec 2008
 
7
Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure.
Komander D, Garg R, …, Ridley AJ, Barford D
EMBO J 2008 Dec 3 27(23):3175-85 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Matthias Buck
Evaluated 5 Jan 2009
 
8
Exceptional
F1000 Factor 8.3

Hypothesis
New Finding
 A Role for the ESCRT System in Cell Division in Archaea.
Samson RY, Obita T, …, Williams RL, Bell SD
Science 2008 Nov 13 [abstract on PubMed] [related articles] [full text]
Selected by | Linda Amos / Harold Erickson / Mohan Balasubramanian with Ramanujam Srinivasan and Mithilesh Mishra / Tom Stevens with Emily M. Coonrod
First evaluation 17 Nov 2008 | Latest evaluation 18 Dec 2008
 
9
Must Read
F1000 Factor 6.6

Confirmation
Hypothesis
New Finding
 Gibberellin-induced DELLA recognition by the gibberellin receptor GID1.
Murase K, Hirano Y, Sun TP, Hakoshima T
Nature 2008 Nov 27 456(7221):459-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Nathan Nelson with Alexey Amunts / Hao Wu with Qian Yin / Eric Lam
First evaluation 8 Dec 2008 | Latest evaluation 6 Jan 2009
 
10
Must Read
F1000 Factor 6.4

Confirmation
Hypothesis
New Finding
 Kinetochore-microtubule attachment relies on the disordered N-terminal tail domain of hec1.
Guimaraes GJ, Dong Y, McEwen BF, Deluca JG
Curr Biol 2008 Nov 25 18(22):1778-84 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Silke Hauf / Linda Amos
First evaluation 12 Dec 2008 | Latest evaluation 17 Dec 2008

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