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 MOST VIEWED PAPERS | Molecular Medicine | calculated on 7 January 2009
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1
Exceptional
F1000 Factor 10.2

Hypothesis
New Finding
Tech Advance
Controversial
Novel Drug Target
 Efficient tumour formation by single human melanoma cells.
Quintana E, Shackleton M, …, Johnson TM, Morrison SJ
Nature 2008 Dec 4 456(7222):593-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ze'ev Ronai / Ruth Roberts / Dafna Bar-Sagi with Elda Grabocka / John Lazo
First evaluation 9 Dec 2008 | Latest evaluation 7 Jan 2009

 
2
Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Neural markers of inhibition in human memory retrieval.
Wimber M, Bäuml KH, …, Heinze HJ, Richardson-Klavehn A
J Neurosci 2008 Dec 10 28(50):13419-27 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Terry Davidson
Evaluated 22 Dec 2008
 
3
Exceptional
F1000 Factor 9.0

Confirmation
New Finding
Novel Drug Target
 A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection.
Pollin TI, Damcott CM, …, O'Connell JR, Shuldiner AR
Science 2008 Dec 12 322(5908):1702-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Henry Ginsberg
Evaluated 2 Jan 2009
 
4
Exceptional
F1000 Factor 9.0

New Finding
Novel Drug Target
 Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.
Van Zeebroeck G, Bonini BM, Versele M, Thevelein JM
Nat Chem Biol 2009 Jan 5(1):45-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Taylor
Evaluated 22 Dec 2008
 
5
Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
 Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.
Hill JA, Hall JA, …, Mathis D, Benoist C
Immunity 2008 Nov 29(5):758-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Laurence Morel
Evaluated 22 Dec 2008
 
6
Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Novel Drug Target
 Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system.
Cayrol R, Wosik K, …, Stanimirovic D, Prat A
Nat Immunol 2008 Feb 9(2):137-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Harrison with Paul Marvar
Evaluated 19 Dec 2008
 
7
Exceptional
F1000 Factor 8.0

Hypothesis
New Finding
Tech Advance
 Bleach activates a redox-regulated chaperone by oxidative protein unfolding.
Winter J, Ilbert M, …, Ozcelik D, Jakob U
Cell 2008 Nov 14 135(4):691-701 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philip Burcham / Bruce Demple
Evaluated 8 Dec 2008
 
8
Exceptional
F1000 Factor 8.0

Hypothesis
New Finding
Tech Advance
Novel Drug Target
 Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.
Louvet C, Szot GL, …, Weiss A, Bluestone JA
Proc Natl Acad Sci U S A 2008 Dec 2 105(48):18895-900 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steven A. Rosenzweig / Daniel Flynn
First evaluation 8 Dec 2008 | Latest evaluation 12 Dec 2008
 
9
Exceptional
F1000 Factor 8.3

Hypothesis
New Finding
 A Role for the ESCRT System in Cell Division in Archaea.
Samson RY, Obita T, …, Williams RL, Bell SD
Science 2008 Nov 13 [abstract on PubMed] [related articles] [full text]
Selected by | Linda Amos / Harold Erickson / Mohan Balasubramanian with Ramanujam Srinivasan and Mithilesh Mishra / Tom Stevens with Emily M. Coonrod
First evaluation 17 Nov 2008 | Latest evaluation 18 Dec 2008
 
10
Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice.
Krohn R, Raffetseder U, …, Mertens PR, Weber C
Circulation 2007 Oct 16 116(16):1812-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Harrison with Klaudia Budzyn
Evaluated 20 May 2008

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