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 MOST VIEWED PAPERS | Biotechnology | calculated on 7 January 2009
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1
Must Read
F1000 Factor 6.0

Confirmation
Tech Advance
 High-resolution mapping of copy-number alterations with massively parallel sequencing.
Chiang DY, Getz G, …, Meyerson M, Lander ES
Nat Methods 2008 Nov 30 [abstract on PubMed] [related articles] [full text]
Selected by | Pui-Yan Kwok
Evaluated 2 Jan 2009
 
2
Exceptional
F1000 Factor 14.5

Hypothesis
New Finding
Controversial
 Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis.
Lolle SJ, Victor JL, Young JM, Pruitt RE
Nature 2005 Mar 24 434(7032):505-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frank Lyko / Shigeru Iida / Kay Schneitz / Judy Wall / Marjori Matzke / James Carrington / Jose Luis Riechmann / Christian Hardtke / John Bowman / James Hu / Caren Chang / Venkatesan Sundaresan / Philip Benfey / Stephan Beck / Magnus Nordborg / Neelima Sinha / Martin Parniske / Elena Alvarez-Buylla / Elizabeth Kellogg / Elizabeth Hood
Dissenters | Alejandro Sanchez-Alvarado
First evaluation 24 Mar 2005 | Latest evaluation 24 May 2005

 
3
Recommended
F1000 Factor 3.0

Tech Advance
 The better tag remains unseen.
Durst FG, Ou HD, …, Dötsch V, Straub WE
J Am Chem Soc 2008 Nov 12 130(45):14932-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Ball with Victoria A. Higman
Evaluated 5 Dec 2008
 
4
Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Tech Advance
 PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.
Singh R, Manjunatha U, …, Jiricek J, Barry CE
Science 2008 Nov 28 322(5906):1392-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Barry Stoddard
Evaluated 2 Jan 2009
 
5
Exceptional
F1000 Factor 10.7

Hypothesis
New Finding
Controversial
 Species-specific transcription in mice carrying human chromosome 21.
Wilson MD, Barbosa-Morais NL, …, Tavaré S, Odom DT
Science 2008 Oct 17 322(5900):434-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yoav Gilad / Kenneth Zaret / Deyou Zheng / Julin Maloof with Jose M. Jimenez-Gomez / Lin Chen with Reza Kalhor / Tom Misteli with Evi Soutoglou / Heng Zhu
First evaluation 13 Oct 2008 | Latest evaluation 23 Dec 2008
 
6
Exceptional
F1000 Factor 8.0

Hypothesis
New Finding
Tech Advance
Novel Drug Target
 Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.
Louvet C, Szot GL, …, Weiss A, Bluestone JA
Proc Natl Acad Sci U S A 2008 Dec 2 105(48):18895-900 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steven A. Rosenzweig / Daniel Flynn
First evaluation 8 Dec 2008 | Latest evaluation 12 Dec 2008
 
7
Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure.
Komander D, Garg R, …, Ridley AJ, Barford D
EMBO J 2008 Dec 3 27(23):3175-85 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Matthias Buck
Evaluated 5 Jan 2009
 
8
Must Read
F1000 Factor 6.0

Hypothesis
 Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors.
Butelli E, Titta L, …, Luo J, Martin C
Nat Biotechnol 2008 Nov 26(11):1301-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alisdair Fernie with Takayuki Tohge
Evaluated 2 Jan 2009
 
9
Exceptional
F1000 Factor 9.9

Confirmation
Hypothesis
New Finding
Tech Advance
 A single-cell view on the ecophysiology of anaerobic phototrophic bacteria.
Musat N, Halm H, …, Jørgensen BB, Kuypers MM
Proc Natl Acad Sci U S A 2008 Nov 18 105(46):17861-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michael Wagner / Carlos Pedrós-Alió / Douglas Bartlett / John Hobbie with Zoe Cardon
First evaluation 26 Nov 2008 | Latest evaluation 2 Jan 2009
 
10
Recommended
F1000 Factor 3.0

Tech Advance
 Nanoscale imaging of molecular positions and anisotropies.
Gould TJ, Gunewardene MS, …, Gosse JA, Hess ST
Nat Methods 2008 Dec 5(12):1027-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stuart S. Licht
Evaluated 5 Jan 2009

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