Faculty of 1000 Biology | Most-viewed Top 10

6-Oct-2008

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	Must Read
F1000 Factor 6.4

Hypothesis

The importance of stupidity in scientific research.
Schwartz MA
J Cell Sci 2008 Jun 1 121(Pt 11):1771 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Beverly Wendland / Orion Weiner

First evaluation 8 Sep 2008 | Latest evaluation 2 Oct 2008

	Exceptional
F1000 Factor 9.8

Confirmation

Hypothesis

New Finding

Tech Advance

Controversial

Internally generated cell assembly sequences in the rat hippocampus.
Pastalkova E, Itskov V, Amarasingham A, Buzsáki G
Science 2008 Sep 5 321(5894):1322-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Michael E. Hasselmo / Howard Eichenbaum / Edvard I. Moser
First evaluation 17 Sep 2008 | Latest evaluation 26 Sep 2008

	Exceptional
F1000 Factor 9.6

Confirmation

New Finding

High-Quality Binary Protein Interaction Map of the Yeast Interactome Network.
Yu H, Braun P, …, Hill DE, Vidal M
Science 2008 Aug 21 [abstract on PubMed] [related articles] [full text]

Selected by | Hunter Fraser / Charles Auffray
First evaluation 12 Sep 2008 | Latest evaluation 25 Sep 2008

	Recommended
F1000 Factor 3.0

Confirmation

The impact of microRNAs on protein output.
Baek D, Villén J, …, Gygi SP, Bartel DP
Nature 2008 Sep 4 455(7209):64-71 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Ulf Pettersson
Evaluated 22 Sep 2008

	Exceptional
F1000 Factor 9.0

Confirmation

Hypothesis

New Finding

Controversial

Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution.
Drummond DA, Wilke CO
Cell 2008 Jul 25 134(2):341-52 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Eugene Koonin
Evaluated 24 Sep 2008

	Exceptional
F1000 Factor 8.0

Hypothesis

New Finding

Tech Advance

In vivo imaging of oskar mRNA transport reveals the mechanism of posterior localization.
Zimyanin VL, Belaya K, …, Davis I, St Johnston D
Cell 2008 Sep 5 134(5):843-53 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Michael Kiebler / Anna Akhmanova
First evaluation 15 Sep 2008 | Latest evaluation 24 Sep 2008

	Exceptional
F1000 Factor 9.8

Hypothesis

New Finding

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.
Zhou Q, Brown J, …, Rajagopal J, Melton DA
Nature 2008 Aug 27 [abstract on PubMed] [related articles] [full text]

Selected by | Anthony Means / Phillip Newmark / John Mullins with L Mullins
First evaluation 4 Sep 2008 | Latest evaluation 18 Sep 2008

	Exceptional
F1000 Factor 9.8

Confirmation

Hypothesis

New Finding

Tech Advance

Novel Drug Target

The crystal structure of a mammalian fatty acid synthase.
Maier T, Leibundgut M, Ban N
Science 2008 Sep 5 321(5894):1315-22 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Russ Hille / David Cane / Senyon Choe

First evaluation 15 Sep 2008 | Latest evaluation 30 Sep 2008

	Must Read
F1000 Factor 6.0

New Finding

Tech Advance

Defining genetic interaction.
Mani R, St Onge RP, …, Giaever G, Roth FP
Proc Natl Acad Sci U S A 2008 Mar 4 105(9):3461-6 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Arcady Mushegian
Evaluated 16 Sep 2008

	Exceptional
F1000 Factor 9.0

Confirmation

New Finding

Solution structure of the integral human membrane protein VDAC-1 in detergent micelles.
Hiller S, Garces RG, …, Colombini M, Wagner G
Science 2008 Aug 29 321(5893):1206-10 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | D. Peter Tieleman
Evaluated 23 Sep 2008

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