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  Sections Covered
Biocatalysis
Bioinorganic Chemistry
Biomacromolecule-Ligand Interactions
Biomimetic Chemistry
Cell Signalling & Trafficking Structures
Chemical Biology of the Cell
Directed Molecular Evolution
Experimental Biophysical Methods
Macromolecular Assemblies & Machines
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Membrane Proteins & Energy Transduction
Protein Chemistry & Proteomics
Protein Folding
Small Molecule Chemistry
Structural Genomics
Structure: RNA
Structure: Replication & Repair
Structure: Transcription & Translation
Theory & Simulation


 HIDDEN JEWELS | Biochemistry | calculated on 7 January 2009
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1
Exceptional
F1000 Factor 9.0

Controversial
Protein dynamical transition does not require protein structure.
He Y, Ku PI, …, Chen JY, Markelz AG
Phys Rev Lett 2008 Oct 24 101(17):178103 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Gruebele with Dr. Simon Ebbinghaus
Evaluated 22 Dec 2008
 
2
Recommended
F1000 Factor 3.0

Tech Advance
The better tag remains unseen.
Durst FG, Ou HD, …, Dötsch V, Straub WE
J Am Chem Soc 2008 Nov 12 130(45):14932-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Ball with Victoria A. Higman
Evaluated 5 Dec 2008
 
3
Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure.
Komander D, Garg R, …, Ridley AJ, Barford D
EMBO J 2008 Dec 3 27(23):3175-85 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Matthias Buck
Evaluated 5 Jan 2009
 
4
Must Read
F1000 Factor 6.4

Confirmation
Hypothesis
New Finding
Kinetochore-microtubule attachment relies on the disordered N-terminal tail domain of hec1.
Guimaraes GJ, Dong Y, McEwen BF, Deluca JG
Curr Biol 2008 Nov 25 18(22):1778-84 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Silke Hauf / Linda Amos
First evaluation 12 Dec 2008 | Latest evaluation 17 Dec 2008
 
5
Must Read
F1000 Factor 4.8

Confirmation
Hypothesis
New Finding
Kinetochore Attachments Require an Interaction between Unstructured Tails on Microtubules and Ndc80(Hec1).
Miller SA, Johnson ML, Stukenberg PT
Curr Biol 2008 Nov 25 18(22):1785-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Silke Hauf / Linda Amos
First evaluation 12 Dec 2008 | Latest evaluation 17 Dec 2008
 
6
Must Read
F1000 Factor 4.8

Hypothesis
New Finding
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.
Narendra D, Tanaka A, Suen DF, Youle RJ
J Cell Biol 2008 Dec 1 183(5):795-803 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kenneth Downing with Alison Killilea / Robert Parton
First evaluation 9 Dec 2008 | Latest evaluation 16 Dec 2008
 
7
Recommended
F1000 Factor 3.0

Tech Advance
Tuning a three-component reaction for trapping kinase substrate complexes.
Statsuk AV, Maly DJ, …, Kuriyan J, Shokat KM
J Am Chem Soc 2008 Dec 24 130(51):17568-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hening Lin
Evaluated 2 Jan 2009
 
8
Must Read
F1000 Factor 6.0

Tech Advance
The multiscale coarse-graining method. I. A rigorous bridge between atomistic and coarse-grained models.
Noid WG, Chu JW, …, Das A, Andersen HC
J Chem Phys 2008 Jun 28 128(24):244114 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Nathan Baker with Marcelo Marucho
Evaluated 5 Jan 2009
 
9
Recommended
F1000 Factor 3.0

Confirmation
New Finding
Architecture and flexibility of the yeast Ndc80 kinetochore complex.
Wang HW, Long S, …, Barnes G, Nogales E
J Mol Biol 2008 Nov 21 383(4):894-903 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Amos
Evaluated 17 Dec 2008
 
10
Exceptional
F1000 Factor 9.0

New Finding
Refutation
Novel Drug Target
Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli.
Boshoff HI, Xu X, …, Williams KJ, Barry CE
J Biol Chem 2008 Jul 11 283(28):19329-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Squire Booker
Evaluated 27 Oct 2008

Hidden Jewels Top 10 lists are generated every day and comprise only papers published in less widely read journals (the grouping of which is the same for all Faculties; therefore, whilst some of these journals may be considered 'high profile' in their immediate Faculty, they are included in the Hidden Jewels lists because they probably will not be so obvious to people outside that specific Faculty). The Hidden Jewels list of papers is ordered by the number of times a paper's evaluation(s) has been viewed over the past 14 days.


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