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Drug Discovery & Design


 HIDDEN JEWELS | Chemical Biology | calculated on 7 January 2009
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1
Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure.
Komander D, Garg R, …, Ridley AJ, Barford D
EMBO J 2008 Dec 3 27(23):3175-85 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Matthias Buck
Evaluated 5 Jan 2009
 
2
Recommended
F1000 Factor 3.0

Tech Advance
Tuning a three-component reaction for trapping kinase substrate complexes.
Statsuk AV, Maly DJ, …, Kuriyan J, Shokat KM
J Am Chem Soc 2008 Dec 24 130(51):17568-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hening Lin
Evaluated 2 Jan 2009
 
3
Exceptional
F1000 Factor 9.0

New Finding
Refutation
Novel Drug Target
Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli.
Boshoff HI, Xu X, …, Williams KJ, Barry CE
J Biol Chem 2008 Jul 11 283(28):19329-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Squire Booker
Evaluated 27 Oct 2008
 
4
Recommended
F1000 Factor 3.0

Tech Advance
Identification of a New Endogenous Metabolite and the Characterization of Its Protein Interactions through an Immobilization Approach.
Kalisiak J, Trauger SA, …, Sharpless KB, Siuzdak G
J Am Chem Soc 2008 Dec 4 [abstract on PubMed] [related articles] [full text]
Selected by | Ross Weatherman
Evaluated 2 Jan 2009
 
5
Recommended
F1000 Factor 3.0

New Finding
Tech Advance
Using an amino acid fluorescence resonance energy transfer pair to probe protein unfolding: application to the villin headpiece subdomain and the LysM domain.
Glasscock JM, Zhu Y, …, Tang J, Gai F
Biochemistry 2008 Oct 21 47(42):11070-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Sterner
Evaluated 10 Dec 2008
 
6
Recommended
F1000 Factor 3.0

Hypothesis
Tech Advance
Enhanced Cleavage of Double-Stranded DNA by Artificial Zinc-Finger Nuclease Sandwiched between Two Zinc-Finger Proteins.
Mineta Y, Okamoto T, …, Aoyama Y, Sera T
Biochemistry 2008 Nov 4 [abstract on PubMed] [related articles] [full text]
Selected by | Amy Barrios with Divya Krishnamurthy
Evaluated 2 Jan 2009
 
7
Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Evidence of a new phosphoryl transfer system in nucleotide metabolism.
Vannoni D, Leoncini R, …, Aceto E, Marinello E
FEBS J 2009 Jan 276(1):271-85 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Barry Stoddard
Evaluated 2 Jan 2009
 
8
Must Read
F1000 Factor 6.0

Hypothesis
Novel Drug Target
Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells.
Bourguignon LY, Peyrollier K, Xia W, Gilad E
J Biol Chem 2008 Jun 20 283(25):17635-51 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Gregg B. Fields
Evaluated 14 Jul 2008
 
9
Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Structure and function of an RNase H domain at the heart of the spliceosome.
Pena V, Rozov A, …, Lührmann R, Wahl MC
EMBO J 2008 Oct 9 [abstract on PubMed] [related articles] [full text]
Selected by | Eric Westhof
Evaluated 30 Oct 2008
 
10
Recommended
F1000 Factor 3.0

New Finding
Tech Advance
Unnatural substrate repertoire of A, B, and X family DNA polymerases.
Hwang GT, Romesberg FE
J Am Chem Soc 2008 Nov 5 130(44):14872-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kuchta
Evaluated 28 Nov 2008

Hidden Jewels Top 10 lists are generated every day and comprise only papers published in less widely read journals (the grouping of which is the same for all Faculties; therefore, whilst some of these journals may be considered 'high profile' in their immediate Faculty, they are included in the Hidden Jewels lists because they probably will not be so obvious to people outside that specific Faculty). The Hidden Jewels list of papers is ordered by the number of times a paper's evaluation(s) has been viewed over the past 14 days.


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