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  Sections Covered
Agriculture & Biotechnology
Applied Microbiology
Biocatalysis
Chemical Biology of the Cell
Drug Discovery & Design
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Small Molecule Chemistry
Structural Genomics


 HIDDEN JEWELS | Biotechnology | calculated on 2 December 2008
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1
Must Read
F1000 Factor 6.0

Hypothesis
Predicting molecules--more realism, please!
Hoffmann R, Schleyer PR, Schaefer HF
Angew Chem Int Ed Engl 2008 47(38):7164-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 20 Nov 2008
 
2
Must Read
F1000 Factor 6.0

Confirmation
Tech Advance
Novel Drug Target
Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase and application for activity imaging in living cells.
Fujikawa Y, Urano Y, …, Inoue H, Nagano T
J Am Chem Soc 2008 Nov 5 130(44):14533-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hening Lin
Evaluated 17 Nov 2008
 
3
Exceptional
F1000 Factor 9.0

Tech Advance
Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules.
Hodis E, Prilusky J, …, Moult J, Sussman JL
Genome Biol 2008 Aug 3 9(8):R121 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Burkhard Rost
Evaluated 29 Oct 2008
 
4
Recommended
F1000 Factor 3.0

Hypothesis
Reconstruction of the genome origins and evolution of the hybrid lager yeast Saccharomyces pastorianus.
Dunn B, Sherlock G
Genome Res 2008 Oct 18(10):1610-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Audrey Gasch
Evaluated 20 Nov 2008
 
5
Must Read
F1000 Factor 6.0

Hypothesis
Refutation
Novel Drug Target
Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes.
Baxter NJ, Blackburn GM, …, Wemmer DE, Waltho JP
J Am Chem Soc 2008 Mar 26 130(12):3952-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Arieh Warshel with Shina Caroline Lynn Kamerlin
Evaluated 13 Nov 2008
 
6
Recommended
F1000 Factor 3.0

New Finding
Cloning and characterization of naringenin 8-prenyltransferase, a flavonoid-specific prenyltransferase of Sophora flavescens.
Sasaki K, Mito K, …, Yamamoto H, Yazaki K
Plant Physiol 2008 Mar 146(3):1075-84 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lloyd W. Sumner
Evaluated 18 Nov 2008
 
7
Must Read
F1000 Factor 4.8

New Finding
Tech Advance
Extreme substrate promiscuity of the Neisseria oligosaccharyltransferase involved in protein O-glycosylation.
Faridmoayer A, Fentabil MA, …, Wang PG, Feldman MF
J Biol Chem 2008 Oct 17 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Miguel Valvano / Barbara Imperiali
First evaluation 30 Oct 2008 | Latest evaluation 19 Nov 2008
 
8
Recommended
F1000 Factor 3.0

New Finding
Tech Advance
Substituted 2-Imino-5-arylidenethiazolidin-4-one Inhibitors of Bacterial Type III Secretion.
Kline T, Felise HB, …, Nguyen HV, Miller SI
J Med Chem 2008 Oct 24 0 [abstract on PubMed] [related articles] [full text]
Selected by | Robert Fecik
Evaluated 13 Nov 2008
 
9
Recommended
F1000 Factor 3.0

New Finding
Tech Advance
Unnatural substrate repertoire of A, B, and X family DNA polymerases.
Hwang GT, Romesberg FE
J Am Chem Soc 2008 Nov 5 130(44):14872-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kuchta
Evaluated 28 Nov 2008
 
10
Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Root-secreted malic Acid recruits beneficial soil bacteria.
Rudrappa T, Czymmek KJ, Paré PW, Bais HP
Plant Physiol 2008 Nov 148(3):1547-56 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Venkatesan Sundaresan
Evaluated 10 Nov 2008

Hidden Jewels Top 10 lists are generated every day and comprise only papers published in less widely read journals (the grouping of which is the same for all Faculties; therefore, whilst some of these journals may be considered 'high profile' in their immediate Faculty, they are included in the Hidden Jewels lists because they probably will not be so obvious to people outside that specific Faculty). The Hidden Jewels list of papers is ordered by the number of times a paper's evaluation(s) has been viewed over the past 14 days.


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