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 ALL TIME TOP 10 | Cancer Biology | calculated on 7 January 2009
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1
Exceptional
F1000 Factor 10.7

Hypothesis
New Finding
 Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication.
Nash P, Tang X, …, Pawson T, Tyers M
Nature 2001 Nov 29 414(6863):514-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sara Courtneidge / Steven Reed / Jeffrey Wade Harper / John Stults / Angel Nebreda / Michael B. Yaffe / Andrius Kazlauskas / Joan Ruderman
First evaluation 12 Dec 2001 | Latest evaluation 18 Feb 2002
 
2
Exceptional
F1000 Factor 10.4

Hypothesis
New Finding
 CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast.
Tanaka S, Umemori T, …, Kamimura Y, Araki H
Nature 2007 Jan 18 445(7125):328-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Etienne Schwob / Stephen Kearsey / Teresa Wang / Nick Rhind / Gennaro D'Urso
First evaluation 23 Jan 2007 | Latest evaluation 11 Apr 2007
 
3
Exceptional
F1000 Factor 10.4

Hypothesis
New Finding
 Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast.
Zegerman P, Diffley JF
Nature 2007 Jan 18 445(7125):281-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Etienne Schwob / Stephen Kearsey / Teresa Wang / Nick Rhind / Gennaro D'Urso
First evaluation 23 Jan 2007 | Latest evaluation 2 Apr 2007
 
4
Exceptional
F1000 Factor 10.3

Hypothesis
New Finding
Tech Advance
 In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Vassilev LT, Vu BT, …, Fotouhi N, Liu EA
Science 2004 Feb 6 303(5659):844-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ulf Pettersson / Liang Tong / Martine Roussel / Jane Endicott / William Kaelin / Dorothee Kern
First evaluation 5 Mar 2004 | Latest evaluation 16 Jun 2004
 
5
Exceptional
F1000 Factor 10.3

Confirmation
Hypothesis
New Finding
 The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis.
Kitajima TS, Kawashima SA, Watanabe Y
Nature 2004 Feb 5 427(6974):510-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robin Allshire / Kevin Hardwick / Mohan Balasubramanian / William Earnshaw / Mark Rose
First evaluation 5 Feb 2004 | Latest evaluation 31 Mar 2004
 
6
Exceptional
F1000 Factor 10.1

Confirmation
New Finding
Tech Advance
 Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories.
Kitamura E, Blow JJ, Tanaka TU
Cell 2006 Jun 30 125(7):1297-308 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joel Huberman / Philippe Pasero / Andrew Belmont / Nick Rhind
First evaluation 13 Jul 2006 | Latest evaluation 13 Dec 2006
 
7
Exceptional
F1000 Factor 10.1

Hypothesis
New Finding
 Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.
Hanks S, Coleman K, …, Douglas J, Rahman N
Nat Genet 2004 Nov 36(11):1159-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marjori Matzke / Kevin Hardwick / Domenico Grieco / Prasad Jallepalli
First evaluation 19 Oct 2004 | Latest evaluation 18 Nov 2004
 
8
Exceptional
F1000 Factor 10.1

Hypothesis
New Finding
 BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
Yang H, Jeffrey PD, …, Lee WH, Pavletich NP
Science 2002 Sep 13 297(5588):1837-48 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ashok Venkitaraman / Kristina Downing / Jane Endicott / Stephen Jackson
First evaluation 16 Sep 2002 | Latest evaluation 24 Oct 2002
 
9
Exceptional
F1000 Factor 10.1

New Finding
 S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast.
Masumoto H, Muramatsu S, Kamimura Y, Araki H
Nature 2002 Feb 7 415(6872):651-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Frederick R. Cross / Susan Forsburg / J. Julian Blow / Hiroto Okayama / Bonita Brewer
First evaluation 4 Feb 2002 | Latest evaluation 14 Aug 2002
 
10
Exceptional
F1000 Factor 10.0

New Finding
Tech Advance
 Replication dynamics of the yeast genome.
Raghuraman MK, Winzeler EA, …, Brewer BJ, Fangman WL
Science 2001 Oct 5 294(5540):115-21 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Dalton / David Allis / Susan Forsburg / Daniel Gottschling
First evaluation 31 Oct 2001 | Latest evaluation 20 Nov 2001

All Time Top 10s are generated every day using papers added to F1000 Biology since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.

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