Faculty of 1000 Biology | All Time Top 10 > Pharmacology & Drug Discovery

2-Dec-2008

Top 10s

Pharmacology & Drug Discovery

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Antimicrobial Agents

Cancer Therapeutics

Cardiovascular Pharmacology

Drug Discovery & Design

Endocrine & Metabolic Pharmacology

Gastrointestinal Pharmacology

Genito-Urinary & Reproductive Pharmacology

Immunopharmacology & Hematologic Pharmacology

Molecular Pharmacology

Musculoskeletal & Dermatologic Pharmacology

Neuropharmacology & Psychopharmacology

Pharmacogenomics

Pharmacokinetics & Drug Delivery

Renal Pharmacology

Respiratory Pharmacology

Toxicology

Related Sections

Bioinformatics

Biomacromolecule-Ligand Interactions

Cell Signalling

Cell Signalling & Trafficking Structures

Chemical Biology of the Cell

Directed Molecular Evolution

Genomics

Macromolecular Chemistry

Medical Genetics

Physiogenomics

Protein Chemistry & Proteomics

Small Molecule Chemistry

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	Exceptional
F1000 Factor 11.3

Hypothesis

New Finding

Tech Advance

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Rasmussen SG, Choi HJ, …, Weis WI, Kobilka BK
Nature 2007 Nov 15 450(7168):383-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Leonardo Pardo / Fred Dyda / Carmen Dessauer / Arthur Christopoulos / Patricia C. Weber / Ian Hall / Marc Caron / Stephan Nussberger
First evaluation 30 Oct 2007 | Latest evaluation 3 Mar 2008

	Exceptional
F1000 Factor 11.3

Confirmation

Hypothesis

New Finding

Tech Advance

Design of a novel globular protein fold with atomic-level accuracy.
Kuhlman B, Dantas G, …, Stoddard BL, Baker D
Science 2003 Nov 21 302(5649):1364-8 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Kristina Downing / Gideon Schreiber / Rob Russell / Wolfgang Guba / Nick Grishin / Padmanabhan Balaram / Robert Kelley / Kevin Plaxco / Sachdev Sidhu
First evaluation 28 Nov 2003 | Latest evaluation 3 Feb 2004

	Exceptional
F1000 Factor 11.1

Hypothesis

New Finding

Novel Drug Target

The inhibitory cytokine IL-35 contributes to regulatory T-cell function.
Collison LW, Workman CJ, …, Blumberg RS, Vignali DA
Nature 2007 Nov 22 450(7169):566-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Steve Ward / Grant Morahan / Thomas Nutman / Mark Smyth / Thomas Hunig / Barry Rouse / Anuradha Ray / Alan Landay / Rachel Caspi / Xiaojing Ma
First evaluation 28 Nov 2007 | Latest evaluation 3 Mar 2008

	Exceptional
F1000 Factor 10.7

Confirmation

Hypothesis

New Finding

Novel Drug Target

Kindlin-3 is essential for integrin activation and platelet aggregation.
Moser M, Nieswandt B, …, Pozgajova M, Fässler R
Nat Med 2008 Mar 14(3):325-30 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Steve Watson / Martin Humphries / Sanford Shattil / Dietmar Vestweber / Xiaoping Du / Klaus Ley / Mark Ginsberg
First evaluation 28 Feb 2008 | Latest evaluation 14 May 2008

	Exceptional
F1000 Factor 10.7

Hypothesis

New Finding

A "silent" polymorphism in the MDR1 gene changes substrate specificity.
Kimchi-Sarfaty C, Oh JM, …, Ambudkar SV, Gottesman MM
Science 2007 Jan 26 315(5811):525-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | J. Steven Leeder / Michael Roth / Richard Maraia / Sue Malcolm / William Dalton / Paul Hollenberg / Tao Pan
First evaluation 30 Jan 2007 | Latest evaluation 19 Nov 2007

	Exceptional
F1000 Factor 10.7

Hypothesis

New Finding

Tech Advance

Controversial

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.
Crowley SD, Gurley SB, …, Le TH, Coffman TM
Proc Natl Acad Sci U S A 2006 Nov 21 103(47):17985-90 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Matthew Breyer / Soeren Sheikh / Raymond Harris / Anna Dominiczak / Tom Lohmeier / David J Webb / Robert Carey
First evaluation 17 Nov 2006 | Latest evaluation 25 Jul 2007

	Exceptional
F1000 Factor 10.7

Hypothesis

New Finding

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication.
Nash P, Tang X, …, Pawson T, Tyers M
Nature 2001 Nov 29 414(6863):514-21 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Sara Courtneidge / Steven Reed / Jeffrey Wade Harper / John Stults / Angel Nebreda / Michael B. Yaffe / Andrius Kazlauskas / Joan Ruderman
First evaluation 12 Dec 2001 | Latest evaluation 18 Feb 2002

	Exceptional
F1000 Factor 10.5

Confirmation

Hypothesis

New Finding

Tech Advance

Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution.
Lange OF, Lakomek NA, …, Griesinger C, de Groot BL
Science 2008 Jun 13 320(5882):1471-5 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Matthias Buck / Gottfried Otting / Antonio Rosato / Torleif Härd / Moosa Mohammadi / Thomas Szyperski
First evaluation 16 Jun 2008 | Latest evaluation 14 Jul 2008

	Exceptional
F1000 Factor 10.5

Hypothesis

New Finding

Tech Advance

Controversial

Novel Drug Target

The consensus coding sequences of human breast and colorectal cancers.
Sjöblom T, Jones S, …, Kinzler KW, Velculescu VE
Science 2006-09-07 314(5797):268-74 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Channing Der / Chris Sander / Karin Schmitt / Charles Streuli / Kai Zinn / Robert Copeland
First evaluation 3 Oct 2006 | Latest evaluation 13 Dec 2006

	Exceptional
F1000 Factor 10.4

Confirmation

Hypothesis

New Finding

Controversial

Novel Drug Target

AMPK and PPARdelta agonists are exercise mimetics.
Narkar VA, Downes M, …, Shaw RJ, Evans RM
Cell 2008 Aug 8 134(3):405-15 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Anthony Means / James Timmons / Fredric Wondisford / Markus Ruegg / David Mangelsdorf with Klementina Fon Tacer / Charles Brenner with Katrina L Bogan
First evaluation 12 Aug 2008 | Latest evaluation 30 Oct 2008

All Time Top 10s are generated every day using papers added to F1000 Biology since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.