Faculty of 1000 Biology | All Time Top 10

7-Jan-2009

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Chemical Biology

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All Time Top 10

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Biocatalysis

Bioinorganic Chemistry

Biomimetic Chemistry

Chemical Biology of the Cell

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	Exceptional
F1000 Factor 12.8

Hypothesis

New Finding

Control of gene expression by a natural metabolite-responsive ribozyme.
Winkler WC, Nahvi A, …, Collins JA, Breaker RR
Nature 2004 Mar 18 428(6980):281-6 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | David M.J. Lilley / Richard Maraia / Samuel Butcher / Eric Westhof / Peter Unrau / Scott K. Silverman / Fritz Eckstein / Burckhard Seelig / Andrew D. Sharrocks / Janet Morrow / Andres Jaschke / John Burke / Reinhard Luehrmann
First evaluation 18 Mar 2004 | Latest evaluation 17 May 2004

	Exceptional
F1000 Factor 12.4

Confirmation

New Finding

Tech Advance

Functional organization of the yeast proteome by systematic analysis of protein complexes.
Gavin AC, Bösche M, …, Neubauer G, Superti-Furga G
Nature 2002 Jan 10 415(6868):141-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Michael Blatt / Kiyoshi Nagai / Sue Goo Rhee / Stephen Jackson / Steven Gygi / Guoping Feng / Mark Nelson / Rolf Apweiler / Marilyn Parsons / Miguel Penalva / Marie-Laure Yaspo / Ron Milligan / Michael Kiebler
First evaluation 18 Jan 2002 | Latest evaluation 24 Jul 2007

	Exceptional
F1000 Factor 12.3

New Finding

Tech Advance

Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system.
Livet J, Weissman TA, …, Sanes JR, Lichtman JW
Nature 2007 Nov 1 450(7166):56-62 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Kees Jalink / Alain Ghysen / Jonathan Sweedler / Liqun Luo / Catherine Krull / Markus Ruegg / Stanley Appel / David P. Wolfer / Andy Groves / Bruce Cumming / Guoping Feng / Edvard I. Moser / Etienne Joly / Martine Roussel
First evaluation 8 Nov 2007 | Latest evaluation 22 Jan 2008

	Exceptional
F1000 Factor 11.7

Hypothesis

New Finding

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.
Iijima M, Devreotes P
Cell 2002 May 31 109(5):599-610 [abstract on PubMed] [related articles] [order article]

Selected by | Silvia Arber / Silvio Gutkind / Steve Ward / Bruce Conklin / Phillip Hawkins / Jeffrey Axelrod / Henry R. Bourne / David Lambright / Anna Huttenlocher / Andreas Wodarz / Richard Gomer / Gerald Weeks
First evaluation 5 Jun 2002 | Latest evaluation 13 Aug 2002

	Exceptional
F1000 Factor 11.3

Confirmation

Hypothesis

New Finding

Tech Advance

Design of a novel globular protein fold with atomic-level accuracy.
Kuhlman B, Dantas G, …, Stoddard BL, Baker D
Science 2003 Nov 21 302(5649):1364-8 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Kristina Downing / Gideon Schreiber / Rob Russell / Wolfgang Guba / Nick Grishin / Padmanabhan Balaram / Robert Kelley / Kevin Plaxco / Sachdev Sidhu
First evaluation 28 Nov 2003 | Latest evaluation 3 Feb 2004

	Exceptional
F1000 Factor 11.1

Hypothesis

New Finding

Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis.
Funamoto S, Meili R, …, Parry L, Firtel RA
Cell 2002 May 31 109(5):611-23 [abstract on PubMed] [related articles] [order article]

Selected by | Silvio Gutkind / Steve Ward / Bruce Conklin / Phillip Hawkins / Jeffrey Axelrod / Henry R. Bourne / David Lambright / Andreas Wodarz / Gerald Weeks
First evaluation 19 Jun 2002 | Latest evaluation 13 Aug 2002

	Exceptional
F1000 Factor 10.9

New Finding

Tech Advance

A photoactivatable GFP for selective photolabeling of proteins and cells.
Patterson GH, Lippincott-Schwartz J
Science 2002 Sep 13 297(5588):1873-7 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Ross Weatherman / Kermit Carraway / Colin Taylor / Karl Oparka / Volkhard Helms / W. Martin Usrey / Rachel Wong / Richard Maraia / Andrew Belmont
First evaluation 23 Sep 2002 | Latest evaluation 15 Nov 2002

	Exceptional
F1000 Factor 10.8

Hypothesis

New Finding

A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA.
Martick M, Horan LH, Noller HF, Scott WG
Nature 2008 Aug 14 454(7206):899-902 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Robert Batey / Thorsten Dieckmann / Sabine Müller / Fritz Eckstein / Andres Jaschke / Barry Stoddard / Ian Willis / Eric Westhof
First evaluation 16 Jul 2008 | Latest evaluation 22 Aug 2008

	Exceptional
F1000 Factor 10.8

Hypothesis

New Finding

Tech Advance

Transvascular delivery of small interfering RNA to the central nervous system.
Kumar P, Wu H, …, Shankar P, Manjunath N
Nature 2007 Jul 5 448(7149):39-43 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Richard Vile / Mark Kay / Angela Vincent / Marina Picciotto / Harukazu Nakamura / William H. Colledge / Günter Mayer / Michael Kiebler / Gerald Zamponi
First evaluation 3 Jul 2007 | Latest evaluation 11 Sep 2007

	Exceptional
F1000 Factor 10.8

Hypothesis

New Finding

Tech Advance

Folding DNA to create nanoscale shapes and patterns.
Rothemund PW
Nature 2006 Mar 16 440(7082):297-302 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Richard Willson / Bino John / Chengde Mao / John Reif / Sabine Müller / Etienne Joly / Kenneth Zaret
First evaluation 20 Mar 2006 | Latest evaluation 30 May 2006

All Time Top 10s are generated every day using papers added to F1000 Biology since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.