Faculty of 1000 Biology | All Time Top 10

7-Jan-2009

Top 10s

Molecular Biology

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Control of Gene Expression

Nuclear Structure & Function

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	Exceptional
F1000 Factor 12.8

Hypothesis

New Finding

Control of gene expression by a natural metabolite-responsive ribozyme.
Winkler WC, Nahvi A, …, Collins JA, Breaker RR
Nature 2004 Mar 18 428(6980):281-6 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | David M.J. Lilley / Richard Maraia / Samuel Butcher / Eric Westhof / Peter Unrau / Scott K. Silverman / Fritz Eckstein / Burckhard Seelig / Andrew D. Sharrocks / Janet Morrow / Andres Jaschke / John Burke / Reinhard Luehrmann
First evaluation 18 Mar 2004 | Latest evaluation 17 May 2004

	Exceptional
F1000 Factor 11.7

Confirmation

Hypothesis

New Finding

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.
Shi Y, Lan F, …, Casero RA, Shi Y
Cell 2004 Dec 29 119(7):941-53 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Steven Henikoff / Thomas Jenuwein / Chris Sander / Winship Herr / Dinah Singer / Robert Dutnall / Eric Selker / Frank Lyko / Daniel Reines / Benoit Coulombe / Robin Allshire
First evaluation 21 Dec 2004 | Latest evaluation 3 Feb 2005

	Exceptional
F1000 Factor 11.2

Confirmation

Hypothesis

New Finding

Tech Advance

A genomic code for nucleosome positioning.
Segal E, Fondufe-Mittendorf Y, …, Wang JP, Widom J
Nature 2006 Aug 17 442(7104):772-8 [abstract on PubMed] [related articles] [order article]

Selected by | Brad Bernstein / Tom Misteli / Kerry Bloom / Nick Rhind / James Bone / Francesc Posas / Michael Meisterernst / Leonie Ringrose / Gabriele Varani
First evaluation 27 Jul 2006 | Latest evaluation 13 Dec 2006

	Exceptional
F1000 Factor 11.0

Hypothesis

New Finding

Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi.
Volpe TA, Kidner C, …, Grewal SI, Martienssen RA
Science 2002 Sep 13 297(5588):1833-7 [abstract on PubMed] [related articles] [FREE full text]

Selected by | L. Alison McInnes / Robin Allshire / Rivka Dikstein / Frank Lyko / Timothy Yen / Kerry Bloom / James Carrington / Thomas Jenuwein
First evaluation 17 Sep 2002 | Latest evaluation 18 Oct 2002

	Exceptional
F1000 Factor 10.9

New Finding

Tech Advance

A photoactivatable GFP for selective photolabeling of proteins and cells.
Patterson GH, Lippincott-Schwartz J
Science 2002 Sep 13 297(5588):1873-7 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Ross Weatherman / Kermit Carraway / Colin Taylor / Karl Oparka / Volkhard Helms / W. Martin Usrey / Rachel Wong / Richard Maraia / Andrew Belmont
First evaluation 23 Sep 2002 | Latest evaluation 15 Nov 2002

	Exceptional
F1000 Factor 10.6

Tech Advance

A system for stable expression of short interfering RNAs in mammalian cells.
Brummelkamp TR, Bernards R, Agami R
Science 2002 Apr 19 296(5567):550-3 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Sharad Kumar / Ashok Venkitaraman / William Kaelin / Michael Meisterernst / Richard Vile / David Glover / Andrea Barta
First evaluation 22 Apr 2002 | Latest evaluation 27 May 2002

	Exceptional
F1000 Factor 10.6

New Finding

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
Epstein AC, Gleadle JM, …, Schofield CJ, Ratcliffe PJ
Cell 2001 Oct 5 107(1):43-54 [abstract on PubMed] [related articles] [order article]

Selected by | Stefan Jentsch / Ronald Conaway / William Kaelin / Ueli Schibler / David Greenstein / Andrius Kazlauskas / Christer Betsholtz
First evaluation 28 Oct 2001 | Latest evaluation 29 Jan 2002

	Exceptional
F1000 Factor 10.5

Confirmation

Hypothesis

New Finding

Tech Advance

Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function.
Lécuyer E, Yoshida H, …, Tomancak P, Krause HM
Cell 2007 Oct 5 131(1):174-87 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Talila Volk / Ken Irvine / Michael Sendtner / Elizabeth Gavis / Roy Long / Paul Lasko / Douglas Turner
First evaluation 18 Oct 2007 | Latest evaluation 10 Mar 2008

	Exceptional
F1000 Factor 10.5

Hypothesis

New Finding

Tech Advance

Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression.
Winkler W, Nahvi A, Breaker RR
Nature 2002 Oct 31 419(6910):952-6 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | John Burke / Richard Maraia / Richard Gourse / Andrew Ellington / Niles Lehman / Gabriele Varani
First evaluation 7 Nov 2002 | Latest evaluation 22 Jan 2003

	Exceptional
F1000 Factor 10.4

Hypothesis

New Finding

CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast.
Tanaka S, Umemori T, …, Kamimura Y, Araki H
Nature 2007 Jan 18 445(7125):328-32 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Etienne Schwob / Stephen Kearsey / Teresa Wang / Nick Rhind / Gennaro D'Urso
First evaluation 23 Jan 2007 | Latest evaluation 11 Apr 2007

All Time Top 10s are generated every day using papers added to F1000 Biology since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.