Faculty of 1000 Biology | All Time Top 10

7-Jan-2009

Top 10s

Microbiology

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Applied Microbiology

Cellular Microbiology & Pathogenesis

Environmental Microbiology

Medical Microbiology

Microbial Evolution & Genomics

Microbial Growth & Development

Microbial Physiology & Metabolism

Parasitology

Virology

Related Sections

Antimicrobial Agents

Immunity to Infections

Innate Immunity

Plant-Biotic Interactions

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	Exceptional
F1000 Factor 12.4

Confirmation

New Finding

Tech Advance

Functional organization of the yeast proteome by systematic analysis of protein complexes.
Gavin AC, Bösche M, …, Neubauer G, Superti-Furga G
Nature 2002 Jan 10 415(6868):141-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Michael Blatt / Kiyoshi Nagai / Sue Goo Rhee / Stephen Jackson / Steven Gygi / Guoping Feng / Mark Nelson / Rolf Apweiler / Marilyn Parsons / Miguel Penalva / Marie-Laure Yaspo / Ron Milligan / Michael Kiebler
First evaluation 18 Jan 2002 | Latest evaluation 24 Jul 2007

	Exceptional
F1000 Factor 12.4

Confirmation

Hypothesis

New Finding

Tech Advance

Controversial

X-ray structure of a protein-conducting channel.
Van den Berg B, Clemons WM, …, Harrison SC, Rapoport TA
Nature 2004 Jan 1 427(6969):36-44 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Koreaki Ito / Karin Romisch / Jia-huai Wang / Stephen White / Tracy Palmer / Davis Ng / Senyon Choe / Ada Yonath / Kiyoshi Nagai / Manfred Schliwa / Bernd Bukau / Douglas Freymann
First evaluation 22 Dec 2003 | Latest evaluation 2 Mar 2004

	Exceptional
F1000 Factor 12.1

Hypothesis

New Finding

Tech Advance

Restoring function in exhausted CD8 T cells during chronic viral infection.
Barber DL, Wherry EJ, …, Freeman GJ, Ahmed R
Nature 2006 Feb 9 439(7077):682-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Barry Rouse / Etienne Joly / Christian Engwerda / Nicholas Restifo / Allan Zajac / Linda Bradley / Jonathan Green / Lieping Chen / Luis J. Montaner / Arthur Hurwitz / Grant McFadden / Matthias von Herrath / Scott Gray-Owen
First evaluation 10 Jan 2006 | Latest evaluation 12 Jul 2006

	Exceptional
F1000 Factor 11.7

Hypothesis

New Finding

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.
Iijima M, Devreotes P
Cell 2002 May 31 109(5):599-610 [abstract on PubMed] [related articles] [order article]

Selected by | Silvia Arber / Silvio Gutkind / Steve Ward / Bruce Conklin / Phillip Hawkins / Jeffrey Axelrod / Henry R. Bourne / David Lambright / Anna Huttenlocher / Andreas Wodarz / Richard Gomer / Gerald Weeks
First evaluation 5 Jun 2002 | Latest evaluation 13 Aug 2002

	Exceptional
F1000 Factor 11.4

Confirmation

Hypothesis

New Finding

Phagosomes are competent organelles for antigen cross-presentation.
Houde M, Bertholet S, …, Sacks D, Desjardins M
Nature 2003 Sep 25 425(6956):402-6 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Karin Romisch / Lutz Walter / Francisco Garcia-del Portillo / Caetano Reis e Sousa / Shiv Pillai / Frank Momburg / Stefan Kaufmann / Edward Collins / Paul Gleeson / Sergio Grinstein
First evaluation 7 Oct 2003 | Latest evaluation 19 Nov 2003

	Exceptional
F1000 Factor 11.4

Confirmation

Hypothesis

New Finding

Structure and mechanism of the lactose permease of Escherichia coli.
Abramson J, Smirnova I, …, Kaback HR, Iwata S
Science 2003 Aug 1 301(5633):610-5 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Stephen White / Wil Konings / David Stokes / Mario Amzel / Tracy Palmer / Jonathan Javitch / Wolf B. Frommer / Petra Fromme / Andreas Engel
First evaluation 6 Aug 2003 | Latest evaluation 3 Nov 2003

	Exceptional
F1000 Factor 11.2

Confirmation

Hypothesis

New Finding

Tech Advance

A genomic code for nucleosome positioning.
Segal E, Fondufe-Mittendorf Y, …, Wang JP, Widom J
Nature 2006 Aug 17 442(7104):772-8 [abstract on PubMed] [related articles] [order article]

Selected by | Brad Bernstein / Tom Misteli / Kerry Bloom / Nick Rhind / James Bone / Francesc Posas / Michael Meisterernst / Leonie Ringrose / Gabriele Varani
First evaluation 27 Jul 2006 | Latest evaluation 13 Dec 2006

	Exceptional
F1000 Factor 11.2

Hypothesis

New Finding

Identification of a bacterial type III effector family with G protein mimicry functions.
Alto NM, Shao F, …, Boone C, Dixon JE
Cell 2006 Jan 13 124(1):133-45 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Sachdev Sidhu / Ariel Blocker / Ilan Rosenshine / Guy Tran Van Nhieu / Christoph Dehio / Michael Gold / Drusilla Burns / Pascale Cossart / Channing Der / Victor Nizet / Alfred Wittinghofer
First evaluation 13 Jan 2006 | Latest evaluation 27 Mar 2006

	Exceptional
F1000 Factor 11.2

Confirmation

Hypothesis

New Finding

ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells.
Guermonprez P, Saveanu L, …, Van Endert P, Amigorena S
Nature 2003 Sep 25 425(6956):397-402 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Colin Watts / Lutz Walter / Frank Momburg / Shiv Pillai / Francisco Garcia-del Portillo / Caetano Reis e Sousa / Judith Klumperman / Stefan Kaufmann / Sergio Grinstein
First evaluation 2 Oct 2003 | Latest evaluation 19 Nov 2003

	Exceptional
F1000 Factor 11.1

Hypothesis

New Finding

Novel Drug Target

The inhibitory cytokine IL-35 contributes to regulatory T-cell function.
Collison LW, Workman CJ, …, Blumberg RS, Vignali DA
Nature 2007 Nov 22 450(7169):566-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Steve Ward / Grant Morahan / Thomas Nutman / Mark Smyth / Thomas Hunig / Barry Rouse / Anuradha Ray / Alan Landay / Rachel Caspi / Xiaojing Ma
First evaluation 28 Nov 2007 | Latest evaluation 3 Mar 2008

All Time Top 10s are generated every day using papers added to F1000 Biology since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.