Faculty of 1000 Biology | All Time Top 10

7-Jan-2009

Top 10s

Bioinformatics

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Animal Genetics

Bioinformatics

Biomacromolecule-Ligand Interactions

Cell Signalling & Trafficking Structures

Evolutionary/Comparative Genetics

Experimental Biophysical Methods

Genomics

Macromolecular Assemblies & Machines

Medical Genetics

Membrane Proteins & Energy Transduction

Microbial Evolution & Genomics

Plant Genomes & Evolution

Protein Folding

Structural Genomics

Structure: RNA

Structure: Replication & Repair

Structure: Transcription & Translation

Theory & Simulation

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	Exceptional
F1000 Factor 12.4

Confirmation

New Finding

Tech Advance

Functional organization of the yeast proteome by systematic analysis of protein complexes.
Gavin AC, Bösche M, …, Neubauer G, Superti-Furga G
Nature 2002 Jan 10 415(6868):141-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Michael Blatt / Kiyoshi Nagai / Sue Goo Rhee / Stephen Jackson / Steven Gygi / Guoping Feng / Mark Nelson / Rolf Apweiler / Marilyn Parsons / Miguel Penalva / Marie-Laure Yaspo / Ron Milligan / Michael Kiebler
First evaluation 18 Jan 2002 | Latest evaluation 24 Jul 2007

	Exceptional
F1000 Factor 11.3

Confirmation

Hypothesis

New Finding

Tech Advance

Design of a novel globular protein fold with atomic-level accuracy.
Kuhlman B, Dantas G, …, Stoddard BL, Baker D
Science 2003 Nov 21 302(5649):1364-8 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Kristina Downing / Gideon Schreiber / Rob Russell / Wolfgang Guba / Nick Grishin / Padmanabhan Balaram / Robert Kelley / Kevin Plaxco / Sachdev Sidhu
First evaluation 28 Nov 2003 | Latest evaluation 3 Feb 2004

	Exceptional
F1000 Factor 11.0

Hypothesis

New Finding

Tech Advance

An RNA gene expressed during cortical development evolved rapidly in humans.
Pollard KS, Salama SR, …, Vanderhaeghen P, Haussler D
Nature 2006 Sep 14 443(7108):167-72 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Kevan A. Martin / John Abrams / Deyou Zheng / Andrew Feinberg / Rafael Zardoya / Ali H. Brivanlou / Robert Sapolsky / Gabriele Varani / Christopher A. Walsh
First evaluation 22 Aug 2006 | Latest evaluation 15 Mar 2007

	Exceptional
F1000 Factor 10.7

Hypothesis

New Finding

Controversial

Species-specific transcription in mice carrying human chromosome 21.
Wilson MD, Barbosa-Morais NL, …, Tavaré S, Odom DT
Science 2008 Oct 17 322(5900):434-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Yoav Gilad / Kenneth Zaret / Deyou Zheng / Julin Maloof with Jose M. Jimenez-Gomez / Lin Chen with Reza Kalhor / Tom Misteli with Evi Soutoglou / Heng Zhu
First evaluation 13 Oct 2008 | Latest evaluation 23 Dec 2008

	Exceptional
F1000 Factor 10.5

Hypothesis

New Finding

Tech Advance

Controversial

Novel Drug Target

The consensus coding sequences of human breast and colorectal cancers.
Sjöblom T, Jones S, …, Kinzler KW, Velculescu VE
Science 2006-09-07 314(5797):268-74 [abstract on PubMed] [related articles] [FREE full text]

Selected by | Channing Der / Chris Sander / Karin Schmitt / Charles Streuli / Kai Zinn / Robert Copeland
First evaluation 3 Oct 2006 | Latest evaluation 13 Dec 2006

	Exceptional
F1000 Factor 10.5

Confirmation

Hypothesis

New Finding

Pack-MULE transposable elements mediate gene evolution in plants.
Jiang N, Bao Z, …, Eddy SR, Wessler SR
Nature 2004 Sep 30 431(7008):569-73 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Sheila McCormick / Manyuan Long / Seth J Davis / Neelima Sinha / Marie-Angele Grandbastien
First evaluation 5 Oct 2004 | Latest evaluation 17 Dec 2004

	Exceptional
F1000 Factor 10.4

Hypothesis

New Finding

Tech Advance

Structure-based activity prediction for an enzyme of unknown function.
Hermann JC, Marti-Arbona R, …, Shoichet BK, Raushel FM
Nature 2007 Aug 16 448(7155):775-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Rowena Matthews / Michael Gelb / Karen Allen / Reinhard Sterner / Andrea Mattevi / Giulio Superti-Furga / Shelley Copley
First evaluation 30 Jul 2007 | Latest evaluation 18 Dec 2007

	Exceptional
F1000 Factor 10.4

Hypothesis

New Finding

Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.
Brennecke J, Aravin AA, …, Sachidanandam R, Hannon GJ
Cell 2007 Mar 23 128(6):1089-103 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Jef Boeke / Donald Rio / John Jaenike / Bino John / Michael Kiebler
First evaluation 23 Mar 2007 | Latest evaluation 4 Jun 2007

	Exceptional
F1000 Factor 10.1

Hypothesis

New Finding

Tech Advance

Structure of a complex of the ATPase SecA and the protein-translocation channel.
Zimmer J, Nam Y, Rapoport TA
Nature 2008 Oct 16 455(7215):936-43 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Manfred Schliwa / Ian Collinson / Art Horwich / Martin Pool
First evaluation 31 Oct 2008 | Latest evaluation 28 Nov 2008

	Exceptional
F1000 Factor 10.1

Confirmation

Hypothesis

New Finding

Crystal structure of a rhomboid family intramembrane protease.
Wang Y, Zhang Y, Ha Y
Nature 2006 Nov 9 444(7116):179-80 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Koreaki Ito / Peter Artymiuk / Jia-huai Wang / Stephan Nussberger
First evaluation 18 Oct 2006 | Latest evaluation 13 Mar 2007

All Time Top 10s are generated every day using papers added to F1000 Biology since the project started (Top 10s consider papers evaluated in the preceding month). Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.