Faculty of 1000 Biology | Current Top 10 > Pharmacology & Drug Discovery

Top 10s

Pharmacology & Drug Discovery

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Antimicrobial Agents

Cancer Therapeutics

Cardiovascular Pharmacology

Drug Discovery & Design

Endocrine & Metabolic Pharmacology

Gastrointestinal Pharmacology

Genito-Urinary & Reproductive Pharmacology

Immunopharmacology & Hematologic Pharmacology

Molecular Pharmacology

Musculoskeletal & Dermatologic Pharmacology

Neuropharmacology & Psychopharmacology

Pharmacogenomics

Pharmacokinetics & Drug Delivery

Renal Pharmacology

Respiratory Pharmacology

Toxicology

Related Sections

Bioinformatics

Biomacromolecule-Ligand Interactions

Cell Signalling

Cell Signalling & Trafficking Structures

Chemical Biology of the Cell

Directed Molecular Evolution

Genomics

Macromolecular Chemistry

Medical Genetics

Physiogenomics

Protein Chemistry & Proteomics

Small Molecule Chemistry

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	Exceptional
F1000 Factor 10.2

Hypothesis

New Finding

Tech Advance

Controversial

Novel Drug Target

Efficient tumour formation by single human melanoma cells.
Quintana E, Shackleton M, …, Johnson TM, Morrison SJ
Nature 2008 Dec 4 456(7222):593-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Ze'ev Ronai / Ruth Roberts

/ Dafna Bar-Sagi with Elda Grabocka

/ John Lazo

First evaluation 9 Dec 2008 | Latest evaluation 7 Jan 2009

	Exceptional
F1000 Factor 8.0

Hypothesis

New Finding

Tech Advance

Novel Drug Target

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.
Louvet C, Szot GL, …, Weiss A, Bluestone JA
Proc Natl Acad Sci U S A 2008 Dec 2 105(48):18895-900 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Steven A. Rosenzweig / Daniel Flynn
First evaluation 8 Dec 2008 | Latest evaluation 12 Dec 2008

	Exceptional
F1000 Factor 8.0

Hypothesis

New Finding

Tech Advance

Bleach activates a redox-regulated chaperone by oxidative protein unfolding.
Winter J, Ilbert M, …, Ozcelik D, Jakob U
Cell 2008 Nov 14 135(4):691-701 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Philip Burcham / Bruce Demple
Evaluated 8 Dec 2008

	Must Read
F1000 Factor 4.8

Hypothesis

New Finding

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis.
Bouskra D, Brézillon C, …, Boneca IG, Eberl G
Nature 2008 Nov 27 456(7221):507-10 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Alan Landay / Caetano Reis e Sousa
First evaluation 9 Dec 2008 | Latest evaluation 11 Dec 2008

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.