Faculty of 1000 Biology | Current Top 10

Top 10s

Structural Biology

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Biomacromolecule-Ligand Interactions

Cell Signalling & Trafficking Structures

Experimental Biophysical Methods

Macromolecular Assemblies & Machines

Membrane Proteins & Energy Transduction

Protein Folding

Structural Genomics

Structure: RNA

Structure: Replication & Repair

Structure: Transcription & Translation

Theory & Simulation

Related Sections

Biocatalysis

Protein Chemistry & Proteomics

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	Exceptional
F1000 Factor 8.3

Hypothesis

New Finding

A Role for the ESCRT System in Cell Division in Archaea.
Samson RY, Obita T, …, Williams RL, Bell SD
Science 2008 Nov 13 [abstract on PubMed] [related articles] [full text]

Selected by | Linda Amos / Harold Erickson / Mohan Balasubramanian with Ramanujam Srinivasan and Mithilesh Mishra / Tom Stevens with Emily M. Coonrod
First evaluation 17 Nov 2008 | Latest evaluation 18 Dec 2008

	Exceptional
F1000 Factor 8.0

Hypothesis

New Finding

Tech Advance

Bleach activates a redox-regulated chaperone by oxidative protein unfolding.
Winter J, Ilbert M, …, Ozcelik D, Jakob U
Cell 2008 Nov 14 135(4):691-701 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Philip Burcham / Bruce Demple
Evaluated 8 Dec 2008

	Must Read
F1000 Factor 6.6

Confirmation

Hypothesis

New Finding

Gibberellin-induced DELLA recognition by the gibberellin receptor GID1.
Murase K, Hirano Y, Sun TP, Hakoshima T
Nature 2008 Nov 27 456(7221):459-63 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Nathan Nelson with Alexey Amunts / Hao Wu with Qian Yin / Eric Lam

First evaluation 8 Dec 2008 | Latest evaluation 6 Jan 2009

	Must Read
F1000 Factor 6.4

Confirmation

New Finding

Tech Advance

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax.
Lovell JF, Billen LP, …, Leber B, Andrews DW
Cell 2008 Dec 12 135(6):1074-84 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Peter Colman with W. Douglas Fairlie / Douglas Green with Jerry E. Chipuk
First evaluation 19 Dec 2008 | Latest evaluation 23 Dec 2008

	Must Read
F1000 Factor 6.4

Confirmation

Hypothesis

New Finding

Kinetochore-microtubule attachment relies on the disordered N-terminal tail domain of hec1.
Guimaraes GJ, Dong Y, McEwen BF, Deluca JG
Curr Biol 2008 Nov 25 18(22):1778-84 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Silke Hauf / Linda Amos
First evaluation 12 Dec 2008 | Latest evaluation 17 Dec 2008

	Must Read
F1000 Factor 4.8

Confirmation

Hypothesis

New Finding

Kinetochore Attachments Require an Interaction between Unstructured Tails on Microtubules and Ndc80(Hec1).
Miller SA, Johnson ML, Stukenberg PT
Curr Biol 2008 Nov 25 18(22):1785-91 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Silke Hauf / Linda Amos
First evaluation 12 Dec 2008 | Latest evaluation 17 Dec 2008

	Must Read
F1000 Factor 4.8

Hypothesis

New Finding

Novel Drug Target

Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin.
Byres E, Paton AW, …, Rossjohn J, Beddoe T
Nature 2008 Dec 4 456(7222):648-52 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Dave Bundle / Bruno Goud with Winfried Römer
First evaluation 8 Dec 2008 | Latest evaluation 16 Dec 2008

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.