Faculty of 1000 Biology | Current Top 10

7-Jan-2009

Top 10s

Molecular Medicine

Current Top 10

All Time Top 10

Most-viewed Top 10

Hidden Jewels Top 10

Sections Covered

Antimicrobial Agents

Autoimmunity

Cancer Therapeutics

Cardiovascular Pharmacology

Cardiovascular Physiology/Circulation

Cell Growth & Division

Drug Discovery & Design

Endocrine & Metabolic Pharmacology

Endocrinology

Gastrointestinal Pharmacology

Gastrointestinal Physiology

Genito-Urinary & Reproductive Pharmacology

Immunomodulation

Immunopharmacology & Hematologic Pharmacology

Integrative Physiology

Medical Genetics

Medical Microbiology

Molecular Pharmacology

Muscle & Connective Tissue

Musculoskeletal & Dermatologic Pharmacology

Neural Homeostasis

Neurobiology of Disease & Regeneration

Neuropharmacology & Psychopharmacology

Pharmacogenomics

Pharmacokinetics & Drug Delivery

Physiogenomics

Renal, Fluid & Electrolyte Physiology

Reproductive Physiology

Respiratory physiology

Stem Cells & Regeneration

Toxicology

email [Help]

	Exceptional
F1000 Factor 10.2

Hypothesis

New Finding

Tech Advance

Controversial

Novel Drug Target

Efficient tumour formation by single human melanoma cells.
Quintana E, Shackleton M, …, Johnson TM, Morrison SJ
Nature 2008 Dec 4 456(7222):593-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Ze'ev Ronai / Ruth Roberts

/ Dafna Bar-Sagi with Elda Grabocka

/ John Lazo

First evaluation 9 Dec 2008 | Latest evaluation 7 Jan 2009

	Exceptional
F1000 Factor 8.3

Hypothesis

New Finding

A Role for the ESCRT System in Cell Division in Archaea.
Samson RY, Obita T, …, Williams RL, Bell SD
Science 2008 Nov 13 [abstract on PubMed] [related articles] [full text]

Selected by | Linda Amos / Harold Erickson / Mohan Balasubramanian with Ramanujam Srinivasan and Mithilesh Mishra / Tom Stevens with Emily M. Coonrod
First evaluation 17 Nov 2008 | Latest evaluation 18 Dec 2008

	Exceptional
F1000 Factor 8.0

Hypothesis

New Finding

Tech Advance

Novel Drug Target

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.
Louvet C, Szot GL, …, Weiss A, Bluestone JA
Proc Natl Acad Sci U S A 2008 Dec 2 105(48):18895-900 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Steven A. Rosenzweig / Daniel Flynn
First evaluation 8 Dec 2008 | Latest evaluation 12 Dec 2008

	Exceptional
F1000 Factor 8.0

Hypothesis

New Finding

Tech Advance

Bleach activates a redox-regulated chaperone by oxidative protein unfolding.
Winter J, Ilbert M, …, Ozcelik D, Jakob U
Cell 2008 Nov 14 135(4):691-701 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Philip Burcham / Bruce Demple
Evaluated 8 Dec 2008

	Must Read
F1000 Factor 6.6

Confirmation

Hypothesis

New Finding

Controversial

The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.
Nilsson J, Yekezare M, Minshull J, Pines J
Nat Cell Biol 2008 Dec 10(12):1411-20 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Kevin Hardwick / Domenico Grieco / Silke Hauf
First evaluation 20 Nov 2008 | Latest evaluation 11 Dec 2008

	Must Read
F1000 Factor 4.8

Hypothesis

New Finding

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction.
Topaloglu AK, Reimann F, …, O'Rahilly S, Semple RK
Nat Genet 2008 Dec 11 [abstract on PubMed] [related articles] [full text]

Selected by | Tony Plant / Allan Herbison
First evaluation 18 Dec 2008 | Latest evaluation 22 Dec 2008

	Must Read
F1000 Factor 4.8

Hypothesis

New Finding

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis.
Bouskra D, Brézillon C, …, Boneca IG, Eberl G
Nature 2008 Nov 27 456(7221):507-10 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Alan Landay / Caetano Reis e Sousa
First evaluation 9 Dec 2008 | Latest evaluation 11 Dec 2008

	Recommended
F1000 Factor 3.2

Hypothesis

New Finding

Novel Drug Target

A novel class of modular transporters for vitamins in prokaryotes.
Rodionov DA, Hebbeln P, …, Hanson AD, Eitinger T
J Bacteriol 2009 Jan 191(1):42-51 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Hanjo Hellmann / Hannelore Daniel with Jürgen Stolz

First evaluation 12 Nov 2008 | Latest evaluation 6 Jan 2009

	Recommended
F1000 Factor 3.2

Hypothesis

New Finding

Tech Advance

Controversial

Energy uptake and allocation during ontogeny.
Hou C, Zuo W, …, Brown JH, West GB
Science 2008 Oct 31 322(5902):736-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Raymond Mejia / Susan Akana
First evaluation 25 Nov 2008 | Latest evaluation 17 Dec 2008

	Recommended
F1000 Factor 3.2

New Finding

Self-renewal and expansion of single transplanted muscle stem cells.
Sacco A, Doyonnas R, …, Vitorovic S, Blau HM
Nature 2008 Nov 27 456(7221):502-6 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Carlo Reggiani with Marco Quarta / Silvana Curci
First evaluation 11 Nov 2008 | Latest evaluation 16 Dec 2008

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.