Faculty of 1000 Biology | Current Top 10

4-Jul-2009

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ALL OF BIOLOGY

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	Exceptional
F1000 Factor 9.8

Hypothesis

New Finding

Germline P granules are liquid droplets that localize by controlled dissolution/condensation.
Brangwynne CP, Eckmann CR, …, Jülicher F, Hyman AA
Science 2009 Jun 26 324(5935):1729-32 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Nick Rhind / Anne Spang / Hong-Wei Wang

First evaluation 5 Jun 2009 | Latest evaluation 29 Jun 2009

	Exceptional
F1000 Factor 9.6

New Finding

Novel Drug Target

mTOR regulates memory CD8 T-cell differentiation.
Araki K, Turner AP, …, Larsen CP, Ahmed R
Nature 2009 Jun 21 [abstract on PubMed] [related articles] [full text]

Selected by | Barry Rouse / Marcia Blackman
First evaluation 22 Jun 2009 | Latest evaluation 26 Jun 2009

	Exceptional
F1000 Factor 8.1

Hypothesis

New Finding

Tech Advance

Metatranscriptomics reveals unique microbial small RNAs in the ocean's water column.
Shi Y, Tyson GW, DeLong EF
Nature 2009 May 14 459(7244):266-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Gabriele Varani / Kelly S. Bender and Judy Wall / Douglas Bartlett
First evaluation 3 Jun 2009 | Latest evaluation 24 Jun 2009

	Exceptional
F1000 Factor 8.0

New Finding

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.
Cho YS, Challa S, …, Guildford M, Chan FK
Cell 2009 Jun 12 137(6):1112-23 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | David Wallach / Astar Winoto
First evaluation 18 Jun 2009 | Latest evaluation 25 Jun 2009

	Exceptional
F1000 Factor 8.0

New Finding

Novel Drug Target

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity.
Subramaniam S, Sixt KM, Barrow R, Snyder SH
Science 2009 Jun 5 324(5932):1327-30 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Katie Kelm and George Breese / M. Flint Beal
First evaluation 18 Jun 2009 | Latest evaluation 24 Jun 2009

	Must Read
F1000 Factor 6.8

Confirmation

Hypothesis

New Finding

Controversial

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response.
Sokol CL, Chu NQ, …, Laufer TM, Medzhitov R
Nat Immunol 2009 Jul 10(7):713-20 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Eric Denkers / Shinsuke Taki / Kiyoshi Takeda / Richard Grencis / Caetano Reis e Sousa

First evaluation 3 Jun 2009 | Latest evaluation 2 Jul 2009

	Must Read
F1000 Factor 6.6

Confirmation

Hypothesis

New Finding

Tech Advance

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish.
Niethammer P, Grabher C, Look AT, Mitchison TJ
Nature 2009 Jun 18 459(7249):996-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Anna Huttenlocher / Gary Bokoch

/ Dorothy N Kakoola and Ivan Gerling

First evaluation 9 Jun 2009 | Latest evaluation 30 Jun 2009

	Must Read
F1000 Factor 6.6

Hypothesis

New Finding

Novel Drug Target

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout.
Woodward OM, Köttgen A, …, Guggino WB, Köttgen M
Proc Natl Acad Sci U S A 2009 Jun 23 106(25):10338-42 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Richard J Naftalin / Fabien Sohet and Dominique Eladari / Robert W. Robey, Ph.D. and Susan Bates

First evaluation 25 Jun 2009 | Latest evaluation 29 Jun 2009

	Must Read
F1000 Factor 6.6

Hypothesis

New Finding

A spatial gradient coordinates cell size and mitotic entry in fission yeast.
Moseley JB, Mayeux A, Paoletti A, Nurse P
Nature 2009 Jun 11 459(7248):857-60 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Arne Lindqvist and Rene Medema / Nick Rhind / Christopher McInerny
First evaluation 10 Jun 2009 | Latest evaluation 26 Jun 2009

	Must Read
F1000 Factor 6.5

Hypothesis

New Finding

Novel Drug Target

Enhancing CD8 T-cell memory by modulating fatty acid metabolism.
Pearce EL, Walsh MC, …, Jones RG, Choi Y
Nature 2009 Jun 3 [abstract on PubMed] [related articles] [full text]

Selected by | Allan Zajac / Susan Kaech / John Kyriakis

First evaluation 9 Jun 2009 | Latest evaluation 3 Jul 2009

Top 10s are generated every day using only papers added to F1000 Biology over the preceding month. Papers are ranked according to their F1000 Factor which incorporates both the number of times a paper has been evaluated, and the ratings it received. If any papers have an equal F1000 Factor then the most recently added paper is listed first.