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Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
R Pappu, SR Schwab, I Cornelissen, JP Pereira, JB … - Science, 2007 - sciencemag.org
Lymphocytes require sphingosine-1-phosphate (S1P) receptor-1 to exit lymphoid
organs, but the source(s) of extracellular S1P and whether S1P directly promotes
egress are unknown. By using mice in which the two kinases that generate ...
Cited by 56 - Related articles - Web Search - BL Direct - All 6 versions
Lysophospholipid receptors: Signalling, pharmacology and regulation by lysophospholipid metabolism
D Meyer zu Heringdorf, KH Jakobs - BBA-Biomembranes, 2007 - Elsevier
The lysophospholipids, sphingosine-1-phosphate (S1P), lysophosphatidic acid
(LPA), sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC),
activate diverse groups of G-protein-coupled receptors that are widely ...
Cited by 38 - Related articles - Web Search - All 2 versions
[HTML] ►Functions of the Multifaceted Family of Sphingosine Kinases and Some Close Relatives
S Spiegel, S Milstien - Journal of Biological Chemistry, 2007 - ASBMB
Sphingosine kinases (SphK) 3 are prototypical members of a highly conserved
family of signaling enzymes. They are present in organisms as diverse as
mammals, flies, worms, yeast, and plants and catalyze the phosphorylation ...
Cited by 29 - Related articles - Web Search - All 4 versions
Tipping the gatekeeper: S1P regulation of endothelial barrier function
H Rosen, MG Sanna, SM Cahalan, PJ Gonzalez-Cabrera - Trends in Immunology, 2007 - Elsevier
The lysophospholipid sphingosine 1-phosphate (S1P) is a pleiotropic signaling
lipid present constitutively in plasma, and secreted locally at elevated
concentrations at sites of inflammation. S1P maintains essential variable ...
Cited by 26 - Related articles - Web Search - All 3 versions
FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical …
T Baumruker, A Billich, V Brinkmann - Expert Opin. Investig. Drugs, 2007 - Expert Opinion
FTY720 (fingolimod; 2-amino-2[2-(4-octylphenyl)ethyl]-1,3-propanediol, Novartis)
is the prototype of a new generation of immunomodulators. The drug is the result
of extensive chemical derivatisation based on the natural product myriocin, ...
Cited by 27 - Related articles - Web Search - All 4 versions
Erythrocytes store and release sphingosine 1-phosphate in blood - ►fasebj.org [HTML]
P Hanel, P Andreani, MH Graler - The FASEB Journal, 2007 - FASEB
The blood constituent sphingosine 1-phosphate (S1P) is a specific ligand for
five G-protein-coupled receptors designated S1P 1–5 . Expression of the S1P 1
receptor on lymphocytes is required for their exit from secondary lymphoid ...
Cited by 23 - Related articles - Web Search - BL Direct - All 3 versions
Synthesis and biological evaluation of ?-aminophosphonates as potent, subtype-selective sphingosine … - ►nih.gov [HTML]
FW Foss, AH Snyder, MD Davis, M Rouse, MD Okusa, … - Bioorganic & Medicinal Chemistry, 2007 - Elsevier
The synthesis of N-arylamide phosphonates and related arylether and arylamine
analogues provided potent, subtype-selective agonists and antagonists of the
five known sphingosine 1-phosphate (S1P) receptors (S1P 1–5 ). To this ...
Cited by 18 - Related articles - Web Search - All 4 versions
A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate- … - ►jem.org [HTML]
C Nombela-Arrieta, TR Mempel, SF Soriano, I Mazo, … - Journal of Experimental Medicine, 2007 - Rockefeller Univ Press
Recent observations using multiphoton intravital microscopy (MP-IVM) have
uncovered an unexpectedly high lymphocyte motility within peripheral lymph nodes
(PLNs). Lymphocyte-expressed intracellular signaling molecules governing ...
Cited by 17 - Related articles - Web Search - BL Direct - All 5 versions
Essential role of sphingosine 1 phosphate receptor 2 in pathological angiogenesis of the mouse … - ►nih.gov [HTML]
A Skoura, T Sanchez, K Claffey, SM Mandala, RL … - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig
Sphingosine 1–phosphate (S1P), a multifunctional lipid mediator that signals
via the S1P family of G protein–coupled receptors (S1PR), regulates vascular
maturation, permeability, and angiogenesis. In this study, we explored the ...
Cited by 15 - Related articles - Web Search - BL Direct - All 4 versions
Mapping Pathways Downstream of Sphingosine 1-Phosphate Subtype 1 by Differential Chemical … - ►jbc.org [HTML]
PJ Gonzalez-Cabrera, T Hla, H Rosen - Journal of Biological Chemistry, 2007 - ASBMB
Sphingosine 1-phosphate subtype 1 (S1P 1 ) receptor agonists alter lymphocyte
trafficking and endothelial barrier integrity in vivo. Among these is the
potent, non-selective agonist, FTY720-P, whose mechanism of action has been ...
Cited by 9 - Related articles - Web Search - All 4 versions
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