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Stromal Cell Networks Regulate Lymphocyte Entry, Migration, and Territoriality in Lymph Nodes - ►immunity.com [HTML] 
M Bajénoff, JG Egen, LY Koo, JP Laugier, F Brau, … - Immunity, 2006 - Elsevier
After entry into lymph nodes (LNs), B cells migrate to follicles, whereas T
cells remain in the paracortex, with each lymphocyte type showing apparently
random migration within these distinct areas. Other than chemokines, the ...
Cited by 81 - Related articles - Web Search - All 9 versions

Emerging medicinal roles for lysophospholipid signaling
SE Gardell, AE Dubin, J Chun - Trends in Molecular Medicine, 2006 - Elsevier
The two lysophospholipids (LPs) lysophosphatidic acid and sphingosine
1-phosphate (S1P) regulate diverse biological processes. Over the past decade,
it has become clear that medically relevant LP activities are mediated by ...
Cited by 73 - Related articles - Web Search - All 4 versions

Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
R Pappu, SR Schwab, I Cornelissen, JP Pereira, JB … - Science, 2007 - sciencemag.org
Lymphocytes require sphingosine-1-phosphate (S1P) receptor-1 to exit lymphoid
organs, but the source(s) of extracellular S1P and whether S1P directly promotes
egress are unknown. By using mice in which the two kinases that generate ...
Cited by 56 - Related articles - Web Search - BL Direct - All 6 versions

CC Chemokine Receptor 7 Contributes to Gi-Dependent T Cell Motility in the Lymph Node - ►jimmunol.org [HTML] 
T Okada, JG Cyster - The Journal of Immunology, 2007 - Am Assoc Immnol
Naive T cells migrate extensively within lymph node (LN) T zones to scan for
Ag-bearing dendritic cells. However, the extracellular signals controlling T
cell motility in LNs are not well defined. In this study, by real-time ...
Cited by 36 - Related articles - Web Search - BL Direct - All 3 versions

The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1 … - ►hematologylibrary.org [HTML] 
SG Payne, CA Oskeritzian, R Griffiths, P … - Blood, 2007 - bloodjournal.hematologylibrary.org
FTY720 is a potent immunomodulator drug that inhibits the egress of lymphocytes
from secondary lymphoid tissues and thymus. FTY720 is phosphorylated in vivo by
sphingosine kinase 2 to FTY720-phosphate, which acts as a potent ...
Cited by 27 - Related articles - Web Search - BL Direct - All 5 versions

Thymic microenvironments for T cell differentiation and selection
E Ladi, X Yin, T Chtanova, EA Robey - Nature Immunology, 2006 - nature.com
During thymic development, early T cell progenitors arrive from the bloodstream
and undergo a series of migration, proliferation and differentiation events in
the thymus before returning to the circulation as mature T cells. Each of ...
Cited by 32 - Related articles - Web Search - BL Direct - All 4 versions

Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell … - ►nih.gov [HTML] 
M Idzko, H Hammad, M Nimwegen, M Kool, T Muller, T … - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig
Airway DCs play a crucial role in the pathogenesis of allergic asthma, and
interfering with their function could constitute a novel form of therapy. The
sphingosine 1–phosphate receptor agonist FTY720 is an oral ...
Cited by 34 - Related articles - Web Search - BL Direct - All 6 versions

Tipping the gatekeeper: S1P regulation of endothelial barrier function
H Rosen, MG Sanna, SM Cahalan, PJ Gonzalez-Cabrera - Trends in Immunology, 2007 - Elsevier
The lysophospholipid sphingosine 1-phosphate (S1P) is a pleiotropic signaling
lipid present constitutively in plasma, and secreted locally at elevated
concentrations at sites of inflammation. S1P maintains essential variable ...
Cited by 26 - Related articles - Web Search - All 3 versions

The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46-and NKG2D-activating … - ►hematologylibrary.org [PDF] 
MD Chiesa, S Carlomagno, G Frumento, M Balsamo, C … - Blood, 2006 - bloodjournal.hematologylibrary.org
Romana Conte, Lorenzo Moretta, Alessandro Moretta and Massimo Vitale Mariella
Della Chiesa, Simona Carlomagno, Guido Frumento, Mirna Balsamo, Claudia Cantoni,
... (3998 articles) Neoplasia (3468 articles) Immunobiology (1084 ...
Cited by 27 - Related articles - View as HTML - Web Search - BL Direct - All 5 versions

Imaging the choreography of lymphocyte trafficking and the immune response
MD Cahalan, I Parker - Current Opinion in Immunology, 2006 - Elsevier
The functioning of the immune system depends upon exquisitely choreographed
interactions between its cellular constituents. Two-photon microscopy now
enables us to visualize cell motility and cell–cell interactions deep ...
Cited by 24 - Related articles - Web Search - All 3 versions
 
Key authors:  M Bajénoff - J Cyster - S Gardell - J Egen - L Koo

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