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1: Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17463-8. Epub 2008 Nov 3.
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Antigen-mediated T cell expansion regulated by parallel pathways of death.

Ch'en IL, Beisner DR, Degterev A, Lynch C, Yuan J, Hoffmann A, Hedrick SM.

Division of Biological Sciences and Department of Cellular and Molecular Medicine, University of California, San Diego, CA 92093, USA.

T cells enigmatically require caspase-8, an inducer of apoptosis, for antigen-driven expansion and effective antiviral responses, and yet the pathways responsible for this effect have been elusive. A defect in caspase-8 expression does not affect progression through the cell cycle but causes an abnormally high rate of cell death that is distinct from apoptosis and does not involve a loss of NFkappaB activation. Instead, antigen or mitogen activated Casp8-deficient T cells exhibit an alternative type of cell death similar to programmed necrosis that depends on receptor interacting protein (Ripk1). The selective genetic ablation of caspase-8, NFkappaB, and Ripk1, reveals two forms of cell death that can regulate virus-specific T cell expansion.

Publication Types:
PMID: 18981423 [PubMed - indexed for MEDLINE]

PMCID: PMC2582294 [Available on 2009/05/11]