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Peptide mass fingerprinting using isotopically encoded photo-crosslinking amino acids.

Wilkins BJ, Daggett KA, Cropp TA.

Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.

When isotopically labelled photo-crosslinking amino acids are site-specifically incorporated into proteins, in combination with the corresponding non-labeled analogue, cross-linked tryptic peptides are easily identified in mass spectra via characteristic "doublet" patterns.

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PMID: 18704231 [PubMed - indexed for MEDLINE]