Your browser version may not work well with NCBI's Web applications. More information here...
1: Genes Dev. 2008 Sep 1;22(17):2353-8. Epub 2008 Aug 14.
Related Articles, Links
Click here to read Click here to read
TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription.

Hsu JY, Juven-Gershon T, Marr MT 2nd, Wright KJ, Tjian R, Kadonaga JT.

Section of Molecular Biology, University of California at San Diego, La Jolla, California 92093, USA.

The RNA polymerase II core promoter is a structurally and functionally diverse transcriptional module. RNAi depletion and overexpression experiments revealed a genetic circuit that controls the balance of transcription from two core promoter motifs, the TATA box and the downstream core promoter element (DPE). In this circuit, TBP activates TATA-dependent transcription and represses DPE-dependent transcription, whereas Mot1 and NC2 block TBP function and thus repress TATA-dependent transcription and activate DPE-dependent transcription. This regulatory circuit is likely to be one means by which biological networks can transmit transcriptional signals, such as those from DPE-specific and TATA-specific enhancers, via distinct pathways.

Publication Types:
PMID: 18703680 [PubMed - indexed for MEDLINE]

PMCID: PMC2532932 [Available on 03/01/09]