Your browser version may not work well with NCBI's Web applications. More information here...
1: Org Biomol Chem. 2008 Jun 7;6(11):1895-7. Epub 2008 Apr 14.
Related Articles, Links
Click here to read
Epigenetic remodeling of the fungal secondary metabolome.

Williams RB, Henrikson JC, Hoover AR, Lee AE, Cichewicz RH.

Natural Products Discovery Group, Department of Chemistry and Biochemistry, 620 Parrington Oval, Room 208, University of Oklahoma, Norman, Oklahoma 73019-3032, USA. rhcichewicz@ou.edu

Fungi treated with DNA methyltransferase and histone deacetylase inhibitors exhibited natural product profiles with enhanced chemical diversity demonstrating that small-molecule epigenetic modifiers are effective tools for rationally controlling the native expression of fungal biosynthetic pathways and generating new biomolecules.

Publication Types:
PMID: 18480899 [PubMed - indexed for MEDLINE]