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1: J Biol Chem. 2008 Jan 4;283(1):541-53. Epub 2007 Oct 30.
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Nuclear receptor coactivator PNRC2 regulates energy expenditure and adiposity.

Zhou D, Shen R, Ye JJ, Li Y, Tsark W, Isbell D, Tso P, Chen S.

Department of Surgical Research, Transgenic Mouse Facility, and Animal Resources Center, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.

PNRC2 was identified in our laboratory as a general cofactor for nuclear receptors. To better characterize the physiological function of PNRC2, we used gene-targeting technology to generate PNRC2-null mice (PNRC2(-/-) mice). These PNRC2(-/-) mice are viable and fertile. PNRC2-null mice, especially male mice, are lean and are resistant to high fat diet-induced obesity but without the induction of insulin resistance. Male mice devoid of PNRC2 protein have a higher metabolic rate than wild-type mice. They consume more oxygen and produce more heat. Consistent with reduced adipose mass, the levels of leptin are lower in PNRC2(-/-) mice. This study provides evidence that PNRC2 plays one or more important roles in controlling the energy balance between energy storage and energy expenditure. PNRC2 may be a new target in the treatment of obesity and related metabolic diseases.

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PMID: 17971453 [PubMed - indexed for MEDLINE]