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1: Science. 2007 Oct 19;318(5849):450-3.
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Erratum in:
  • Science. 2007 Dec 21;318(5858):1866.

Comment in:
Permuted tRNA genes expressed via a circular RNA intermediate in Cyanidioschyzon merolae.

Soma A, Onodera A, Sugahara J, Kanai A, Yachie N, Tomita M, Kawamura F, Sekine Y.

Department of Life Science, College of Science, Rikkyo (St. Paul's) University, Toshima, Tokyo 171-8501, Japan.

A computational analysis of the nuclear genome of a red alga, Cyanidioschyzon merolae, identified 11 transfer RNA (tRNA) genes in which the 3' half of the tRNA lies upstream of the 5' half in the genome. We verified that these genes are expressed and produce mature tRNAs that are aminoacylated. Analysis of tRNA-processing intermediates for these genes indicates an unusual processing pathway in which the termini of the tRNA precursor are ligated, resulting in formation of a characteristic circular RNA intermediate that is then processed at the acceptor stem to generate the correct termini.

Publication Types:
PMID: 17947580 [PubMed - indexed for MEDLINE]