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1: PLoS Pathog. 2007 Oct 12;3(10):1380-7.
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Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells.

Millington OR, Gibson VB, Rush CM, Zinselmeyer BH, Phillips RS, Garside P, Brewer JM.

Centre for Biophotonics, University of Strathclyde, Glasgow, United Kingdom.

Interactions between antigen-presenting dendritic cells (DCs) and T cells are essential for the induction of an immune response. However, during malaria infection, DC function is compromised and immune responses against parasite and heterologous antigens are reduced. Here, we demonstrate that malaria infection or the parasite pigment hemozoin inhibits T cell and DC interactions both in vitro and in vivo, while signal 1 intensity remains unaltered. This altered cellular behaviour is associated with the suppression of DC costimulatory activity and functional T cell responses, potentially explaining why immunity is reduced during malaria infection.

Publication Types:
PMID: 17937497 [PubMed - indexed for MEDLINE]

PMCID: PMC2014797