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1: J Exp Med. 2007 Aug 6;204(8):1923-33. Epub 2007 Jul 23.
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Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells.

Sapoznikov A, Fischer JA, Zaft T, Krauthgamer R, Dzionek A, Jung S.

Department of Immunology, The Weizmann Institute of Science, 76100 Rehovot, Israel.

Plasmacytoid dendritic cells (PDCs) play a pivotal role as cytokine-secreting accessory cells in the antimicrobial immune defense. In contrast, the capacity of PDCs to act as antigen-presenting cells in naive T cell priming remains unclear. By studying T cell responses in mice that lack conventional DCs (cDCs), and by the use of a PDC-specific antigen-targeting strategy, we show that PDCs can initiate productive naive CD4(+) T cell responses in lymph nodes, but not in the spleen. PDC-triggered CD4(+) T cell responses differed from cDC-driven responses in that they were not associated with concomitant CD8(+) T cell priming. Our results establish PDCs as a bona fide DC subset that initiates unique CD4(+) Th cell-dominated primary immune responses.

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PMID: 17646404 [PubMed - indexed for MEDLINE]

PMCID: PMC2118686