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1: Science. 2007 Jul 13;317(5835):242-5.
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Postreplicative formation of cohesion is required for repair and induced by a single DNA break.

Ström L, Karlsson C, Lindroos HB, Wedahl S, Katou Y, Shirahige K, Sjögren C.

Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.

Sister-chromatid cohesion, established during replication by the protein complex cohesin, is essential for both chromosome segregation and double-strand break (DSB) repair. Normally, cohesion formation is strictly limited to the S phase of the cell cycle, but DSBs can trigger cohesion also after DNA replication has been completed. The function of this damage-induced cohesion remains unknown. In this investigation, we show that damage-induced cohesion is essential for repair in postreplicative cells in yeast. Furthermore, it is established genome-wide after induction of a single DSB, and it is controlled by the DNA damage response and cohesin-regulating factors. We thus define a cohesion establishment pathway that is independent of DNA duplication and acts together with cohesion formed during replication in sister chromatid-based DSB repair.

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PMID: 17626884 [PubMed - indexed for MEDLINE]