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1: Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11933-8. Epub 2007 Jul 2.
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Src phosphorylation of cortactin enhances actin assembly.

Tehrani S, Tomasevic N, Weed S, Sakowicz R, Cooper JA.

Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. tehranis@medicine.wustl.edu

Src kinase mediates growth factor signaling and causes oncogenic transformation, which includes dramatic changes in the actin cytoskeleton, cell shape, and motility. Cortactin was discovered as a substrate for Src. How phosphorylation of cortactin can enhance actin assembly is unknown. Here, using an actin assembly system reconstituted from purified components, we demonstrate for the first time a biochemical mechanism by which Src phosphorylation of cortactin affects actin assembly. The adaptor Nck is an important component of the system, linking phosphorylated cortactin with neuronal WASp (N-WASp) and WASp-interacting protein (WIP) to activate Arp2/3 complex.

Publication Types:
PMID: 17606906 [PubMed - indexed for MEDLINE]

PMCID: PMC1924558