Your browser version may not work well with NCBI's Web applications. More information here...
1: ACS Chem Biol. 2007 Jun 15;2(6):390-8. Epub 2007 May 25.
Related Articles, Links
Click here to read Click here to read
Comment in:
Thyronamines inhibit plasma membrane and vesicular monoamine transport.

Snead AN, Santos MS, Seal RP, Miyakawa M, Edwards RH, Scanlan TS.

Graduate Program in Chemistry and Chemical Biology, University of California at San Francisco, San Francisco, California 94143, USA.

Thyroid hormone has long been known to have important transcriptional regulatory activities. Recently, however, the presence of endogenous derivatives of thyroid hormone, thyronamines, has been reported in various mammalian tissues. These derivatives have potent in vitro activity with a class of orphan G-protein-coupled receptors, the trace amine-associated receptors, and profound in vivo effects when administered to mice. We report here a novel neuromodulatory role for thyronamines. In synaptosomal preparations and heterologous expression systems, thyronamines act as specific dopamine and norepinephrine reuptake inhibitors. Thyronamines also inhibit the transport of monoamines into synaptic vesicles. These observations expand the nontranscriptional role of thyroid hormone derivatives and may help to explain the pharmacological effects of thyronamines in vivo.

Publication Types:
PMID: 17530732 [PubMed - indexed for MEDLINE]