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1: Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6341-6. Epub 2007 Mar 30.
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Killer T cells regulate antigen presentation for early expansion of memory, but not naive, CD8+ T cell.

Belz GT, Zhang L, Lay MD, Kupresanin F, Davenport MP.

Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3050, Australia. belz@wehi.edu.au

Antigen presentation within the lymph node draining a site of infection is crucial for initiation of cytotoxic T cell responses. Precisely how this antigen presentation regulates T cell expansion in vivo is unclear. Here, we show that, in primary infection, antigen presentation peaks approximately 3 days postinfection and then slowly decays until day 12. This prolonged antigen presentation is required for optimal expansion of naive CD8(+) T cells, because early ablation of dendritic cells reduces the later CD8(+) T cell response. Antigen presentation during secondary infection was 10-fold lower in magnitude and largely terminated by day 4 postinfection. Expansion of memory, but not naive, antigen-specific T cells was tightly controlled by perforin-dependent cytolysis of antigen-presenting cells. The ability of the memory T cells to remove antigen-presenting cells provides a negative-feedback loop to directly limit the duration of antigen presentation in vivo.

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PMID: 17400753 [PubMed - indexed for MEDLINE]

PMCID: PMC1840050