A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer.
Tonks NK, Muthuswamy SK.
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. tonks@cshl.edu
The protein tyrosine phosphatase PTP1B, previously recognized for its role in downregulating insulin and leptin signaling, has now been shown to function as a positive regulator of signaling events associated with breast tumorigenesis. Inhibitors of PTP1B that have been developed as drug candidates for treatment of diabetes and obesity may offer new avenues for the treatment of breast cancer.
PMID: 17349579 [PubMed - indexed for MEDLINE]