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1: Nat Struct Mol Biol. 2007 Mar;14(3):243-5. Epub 2007 Feb 18.
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Erratum in:
  • Nat Struct Mol Biol. 2007 Apr;14(4):351.

Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase.

Liang G, Klose RJ, Gardner KE, Zhang Y.

Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA.

Histone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5' regions of transcribed genes. Here we identify a novel budding yeast JmjC domain-containing H3-K4 demethylase, Jhd2p, that antagonizes the trimethyl modification state and contributes to regulation of telomeric silencing.

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PMID: 17310254 [PubMed - indexed for MEDLINE]