Your browser version may not work well with NCBI's Web applications. More information here...
1: Science. 2007 Mar 9;315(5817):1398-401. Epub 2007 Feb 1.
Related Articles, Links
Click here to read Click here to read
Comment in:
Autophagy-dependent viral recognition by plasmacytoid dendritic cells.

Lee HK, Lund JM, Ramanathan B, Mizushima N, Iwasaki A.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

Plasmacytoid dendritic cells (pDCs) detect viruses in the acidified endosomes by means of Toll-like receptors (TLRs). Yet, pDC responses to certain single-stranded RNA (ssRNA) viruses occur only after live viral infection. We present evidence here that the recognition of such viruses by TLR7 requires transport of cytosolic viral replication intermediates into the lysosome by the process of autophagy. In addition, autophagy was found to be required for the production of interferon-alpha by pDCs. These results support a key role for autophagy in mediating ssRNA virus detection and interferon-alpha secretion by pDCs and suggest that cytosolic replication intermediates of viruses serve as pathogen signatures recognized by TLR7.

Publication Types:
PMID: 17272685 [PubMed - indexed for MEDLINE]