Contact patterns between helices and strands of sheet define protein folding patterns.
Kamat AP, Lesk AM.
Department of Computer Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Comparing and classifying protein folding patterns allows organizing the known structures and enumerating possible protein structural patterns including those not yet observed. We capture the essence of protein folding patterns in a concise tableau representation based on the order and contact patterns of secondary structures: helices and strands of sheet. The tableaux are intelligible to both humans and computers. They provide a database, derived from the Protein Data Bank, mineable in studies of protein architecture. Using this database, we have: (i) determined statistical properties of secondary structure contacts in an unbiased set of protein domains from ASTRAL, (ii) observed that in 98% of cases, the tableau is a faithful representation of the folding pattern as classified in SCOP, (iii) demonstrated that to a large extent the local structure of proteins indicates their complete folding topology, and (iv) studied the use of the representation for fold identification. (c) 2007 Wiley-Liss, Inc.
PMID: 17206659 [PubMed - indexed for MEDLINE]