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1: Science. 2007 Jan 5;315(5808):111-5.
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Differential transmission of actin motion within focal adhesions.

Hu K, Ji L, Applegate KT, Danuser G, Waterman-Storer CM.

Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Cell migration requires the transmission of motion generated in the actin cytoskeleton to the extracellular environment through a complex assembly of proteins in focal adhesions. We developed correlational fluorescent speckle microscopy to measure the coupling of focal-adhesion proteins to actin filaments. Different classes of focal-adhesion structural and regulatory molecules exhibited varying degrees of correlated motions with actin filaments, indicating hierarchical transmission of actin motion through focal adhesions. Interactions between vinculin, talin, and actin filaments appear to constitute a slippage interface between the cytoskeleton and integrins, generating a molecular clutch that is regulated during the morphodynamic transitions of cell migration.

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PMID: 17204653 [PubMed - indexed for MEDLINE]