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1: Science. 2006 Aug 11;313(5788):851-3.
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Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila.

Didelot G, Molinari F, Tchénio P, Comas D, Milhiet E, Munnich A, Colleaux L, Preat T.

Gènes et Dynamique des Systèmes de Mémoire, UMR CNRS 7637, Ecole Supérieure de Physique et de Chimie Industrielles, 10 Rue Vauquelin 75005 Paris, France.

Mutations in the human neurotrypsin gene are associated with autosomal recessive mental retardation. To further understand the pathophysiological consequences of the lack of this serine protease, we studied Tequila (Teq), the Drosophila neurotrypsin ortholog, using associative memory as a behavioral readout. We found that teq inactivation resulted in a long-term memory (LTM)-specific defect. After LTM conditioning of wild-type flies, teq expression transiently increased in the mushroom bodies. Moreover, specific inhibition of teq expression in adult mushroom bodies resulted in a reversible LTM defect. Hence, the Teq pathway is essential for information processing in Drosophila.

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PMID: 16902143 [PubMed - indexed for MEDLINE]