PlyPH, a bacteriolytic enzyme with a broad pH range of activity and lytic action against Bacillus anthracis.
Yoong P, Schuch R, Nelson D, Fischetti VA.
Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
We have cloned a lytic enzyme, PlyPH, with a specific lytic effect on Bacillus anthracis strains. PlyPH remains active between pH 4 and 10.5, and a single dose rescued a significant percentage of mice infected intraperitoneally with an attenuated B. anthracis strain. We propose PlyPH as a novel therapeutic agent.
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PMID: 16547060 [PubMed - indexed for MEDLINE]PMCID: PMC1428399