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1: Nat Neurosci. 2005 Sep;8(9):1142-4. Epub 2005 Aug 7.
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Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons.

McKay LC, Janczewski WA, Feldman JL.

Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, 90095-1763, USA.

Ablation of preBötzinger complex (preBötC) neurons, critical for respiratory rhythm generation, resulted in a progressive, increasingly severe disruption of respiratory pattern, initially during sleep and then also during wakefulness in adult rats. Sleep-disordered breathing is highly prevalent in elderly humans and in some patients with neurodegenerative disease. We propose that sleep-disordered breathing results from loss of preBötC neurons and could underlie death during sleep in these populations.

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PMID: 16116455 [PubMed - indexed for MEDLINE]