Your browser version may not work well with NCBI's Web applications. More information here...
1: Bioinformatics. 2005 May 15;21(10):2287-93. Epub 2005 Mar 29.
Related Articles, Links
Click here to read Click here to read
Quasi-consensus-based comparison of profile hidden Markov models for protein sequences.

Kahsay RY, Wang G, Gao G, Liao L, Dunbrack R.

Delaware Biotechnology Institute, Newark, DE 19715, USA.

A simple approach for the sensitive detection of distant relationships among protein families and for sequence-structure alignment via comparison of hidden Markov models based on their quasi-consensus sequences is presented. Using a previously published benchmark dataset, the approach is demonstrated to give better homology detection and yield alignments with improved accuracy in comparison to an existing state-of-the-art dynamic programming profile-profile comparison method. This method also runs significantly faster and is therefore suitable for a server covering the rapidly increasing structure database. A server based on this method is available at http://liao.cis.udel.edu/website/servers/modmod

Publication Types:
PMID: 15797916 [PubMed - indexed for MEDLINE]