Your browser version may not work well with NCBI's Web applications. More information
here...
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.
Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH.
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Cell lineage specification depends on both gene activation and gene silencing, and in the differentiation of T helper progenitors to Th1 or Th2 effector cells, this requires the action of two opposing transcription factors, T-bet and GATA-3. T-bet is essential for the development of Th1 cells, and GATA-3 performs an equivalent role in Th2 development. We report that T-bet represses Th2 lineage commitment through tyrosine kinase-mediated interaction between the two transcription factors that interferes with the binding of GATA-3 to its target DNA. These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell.
Publication Types:
PMID: 15662016 [PubMed - indexed for MEDLINE]