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1: Nat Neurosci. 2004 Nov;7(11):1195-203. Epub 2004 Oct 10.
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Par6alpha signaling controls glial-guided neuronal migration.

Solecki DJ, Model L, Gaetz J, Kapoor TM, Hatten ME.

Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021, USA.

Neuronal migrations along glial fibers provide a primary pathway for the formation of cortical laminae. To examine the mechanisms underlying glial-guided migration, we analyzed the dynamics of cytoskeletal and signaling components in living neurons. Migration involves the coordinated two-stroke movement of a perinuclear tubulin 'cage' and the centrosome, with the centrosome moving forward before nuclear translocation. Overexpression of mPar6alpha disrupts the perinuclear tubulin cage, retargets PKCzeta and gamma-tubulin away from the centrosome, and inhibits centrosomal motion and neuronal migration. Thus, we propose that during neuronal migration the centrosome acts to coordinate cytoskeletal dynamics in response to mPar6alpha-mediated signaling.

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PMID: 15475953 [PubMed - indexed for MEDLINE]