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1: Genes Dev. 2004 Sep 15;18(18):2225-30. Epub 2004 Sep 1.
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Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.

Brembeck FH, Schwarz-Romond T, Bakkers J, Wilhelm S, Hammerschmidt M, Birchmeier W.

Max Delbrueck Center for Molecular Medicine, 13092 Berlin, Germany.

beta-Catenin controls both cadherin-mediated cell adhesion and activation of Wnt target genes. We demonstrate here that the beta-catenin-binding protein BCL9-2, a homolog of the human proto-oncogene product BCL9, induces epithelial-mesenchymal transitions of nontransformed cells and increases beta-catenin-dependent transcription. RNA interference of BCL9-2 in carcinoma cells induces an epithelial phenotype and translocates beta-catenin from the nucleus to the cell membrane. The switch between beta-catenin's adhesive and transcriptional functions is modulated by phosphorylation of Tyr 142 of beta-catenin, which favors BCL9-2 binding and precludes interaction with alpha-catenin. During zebrafish embryogenesis, BCL9-2 acts in the Wnt8-signaling pathway and regulates mesoderm patterning.

Publication Types:
PMID: 15371335 [PubMed - indexed for MEDLINE]

PMCID: PMC517514