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1: J Immunol. 2004 May 1;172(9):5450-5.
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Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo.

Workman CJ, Cauley LS, Kim IJ, Blackman MA, Woodland DL, Vignali DA.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Lymphocyte activation gene-3 (LAG-3) is a CD4-related, activation-induced cell surface molecule that binds to MHC class II with high affinity. In this study, we used four experimental systems to reevaluate previous suggestions that LAG-3(-/-) mice had no T cell defect. First, LAG-3(-/-) T cells exhibited a delay in cell cycle arrest following in vivo stimulation with the superantigen staphylococcal enterotoxin B resulting in increased T cell expansion and splenomegaly. Second, increased T cell expansion was also observed in adoptive recipients of LAG-3(-/-) OT-II TCR transgenic T cells following in vivo Ag stimulation. Third, infection of LAG-3(-/-) mice with Sendai virus resulted in increased numbers of memory CD4(+) and CD8(+) T cells. Fourth, CD4(+) T cells exhibited a delayed expansion in LAG-3(-/-) mice infected with murine gammaherpesvirus. In summary, these data suggest that LAG-3 negatively regulates T cell expansion and controls the size of the memory T cell pool.

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PMID: 15100286 [PubMed - indexed for MEDLINE]