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Recommended
F1000 Factor 3.0

Confirmation
Tech Advance
Flow analyses in the lower airways: patient-specific model and boundary conditions.
De Backer JW, Vos WG, …, Parizel PM, De Backer W
Med Eng Phys 2008 Sep 30(7):872-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Merryn Tawhai
Evaluated 14 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice.
McKinley L, Alcorn JF, …, Ray A, Kolls JK
J Immunol 2008 Sep 15 181(6):4089-97 [abstract on PubMed] [related articles] [order article]
Selected by | Dan Conrad
Evaluated 31 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
Structure of pulmonary surfactant membranes and films: the role of proteins and lipid-protein interactions.
Pérez-Gil J
Biochim Biophys Acta 2008 Jul-Aug 1778(7-8):1676-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Matthias Ochs
Evaluated 28 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
Budesonide/formoterol maintenance and reliever therapy: impact on airway inflammation in asthma.
Sears MR, Boulet LP, …, Smiljanic-Georgijev N, Lee JS
Eur Respir J 2008 May 31(5):982-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Jeffery
Evaluated 28 Oct 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Novel Drug Target
Effect of salmeterol/fluticasone propionate on airway inflammation in COPD: a randomised controlled trial.
Bourbeau J, Christodoulopoulos P, …, Olivenstein R, Hamid Q
Thorax 2007 Nov 62(11):938-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Jeffery
Evaluated 28 Oct 2008

Exceptional
F1000 Factor 9.0

New Finding
Refutation
Novel Drug Target
Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli.
Boshoff HI, Xu X, …, Williams KJ, Barry CE
J Biol Chem 2008 Jul 11 283(28):19329-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Squire Booker
Evaluated 27 Oct 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages.
Goleva E, Hauk PJ, …, Martin RJ, Leung DY
J Allergy Clin Immunol 2008 Sep 122(3):550-9.e3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lanny Rosenwasser
Evaluated 21 Oct 2008


Recommended
F1000 Factor 3.0

Confirmation
New Finding
Novel Drug Target
Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues.
Tremblay K, Daley D, …, Paré PD, Laprise C
J Allergy Clin Immunol 2008 Sep 122(3):529-36.e17 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lanny Rosenwasser
Evaluated 21 Oct 2008

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
New Finding
Novel Drug Target
Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition.
Audero E, Coppi E, …, Corradetti R, Gross C
Science 2008 Jul 4 321(5885):130-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Shaun Morrison with Kazuhiro Nakamura
Evaluated 21 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis.
Rao SP, Alonso S, …, Dick T, Pethe K
Proc Natl Acad Sci U S A 2008 Aug 19 105(33):11945-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kim Lewis with Lawrence R. Mulcahy
Evaluated 10 Oct 2008


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