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F1000 Factor 3.0

New Finding
Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure.
Watanabe T, Takeda T, …, Shirasawa T, Otsu K
J Am Coll Cardiol 2008 Aug 26 52(9):779-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Frenneaux with Julian O M Ormerod
Evaluated 12 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis.
Wang H, Peters T, …, Weiss JM, Scharffetter-Kochanek K
J Clin Invest 2008 Jul 118(7):2629-39 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mohamed Sayegh with Jessamyn Bagley
Evaluated 21 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis.
Bull MJ, Williams AS, …, Al-Shamkhani A, Wang EC
J Exp Med 2008 Sep 29 [abstract on PubMed] [related articles] [full text]
Selected by | Richard L. Stevens
Evaluated 10 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages.
Ha SD, Martins A, …, Chan BM, Kim SO
J Immunol 2008 Jul 1 181(1):690-7 [abstract on PubMed] [related articles] [order article]
Selected by | Robert Booth
Evaluated 25 Sep 2008

Recommended
F1000 Factor 3.0

Hypothesis
Novel Drug Target
Collagen Fibril Formation: A NEW TARGET TO LIMIT FIBROSIS.
Chung HJ, Steplewski A, …, Uitto J, Fertala A
J Biol Chem 2008 Sep 19 283(38):25879-25886 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Jones
Evaluated 22 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
Antigen-specific apheresis of human anti-acetylcholine receptor autoantibodies from myasthenia gravis patients' sera using Escherichia coli-expressed receptor domains.
Zisimopoulou P, Lagoumintzis G, Poulas K, Tzartos SJ
J Neuroimmunol 2008 Aug 30 200(1-2):133-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lin Chen
Evaluated 17 Sep 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro.
Wang H, Yoshiko Y, …, Aubin JE, Maeda N
J Bone Miner Res 2008 Jun 23(6):939-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Eleanor Lederer
Evaluated 3 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis.
Armand AS, Bourajjaj M, …, Redondo JM, De Windt LJ
J Biol Chem 2008 Aug 1 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lin Chen
Evaluated 2 Sep 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Novel Drug Target
The initiation factor eIF3-f is a major target for atrogin1/MAFbx function in skeletal muscle atrophy.
Lagirand-Cantaloube J, Offner N, …, Segura CT, Leibovitch SA
EMBO J 2008 Apr 23 27(8):1266-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Greenhaff with Andrew Murton
Evaluated 2 Sep 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Trend in incidence of osteoporosis-related fractures among 40- to 69-year-old women: analysis of a large insurance claims database, 2000-2005.
Islam S, Liu Q, Chines A, Helzner E
Menopause 2008 Jul 25 [abstract on PubMed] [related articles] [full text]
Selected by | Henry Burger
Evaluated 21 Aug 2008


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