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Browse > Pharmacology & Drug Discovery > Endocrine & Metabolic Pharmacology
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F1000 Factor 3.0

Hypothesis
New Finding
Novel Drug Target
 Targeting Inactive Enzyme Conformation: Aryl Diketoacid Derivatives as a New Class of PTP1B Inhibitors.
Liu S, Zeng LF, …, Long YQ, Zhang ZY
J Am Chem Soc 2008 Nov 14 0 [abstract on PubMed] [related articles] [full text]
Selected by | Amy Barrios
Evaluated 28 Nov 2008

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F1000 Factor 3.0

Confirmation
New Finding
 Role of ghrelin in the relationship between hyperphagia and accelerated gastric emptying in diabetic mice.
Verhulst PJ, De Smet B, …, Peeters TL, Depoortere I
Gastroenterology 2008 Oct 135(4):1267-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chung Owyang
Evaluated 27 Nov 2008

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F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen.
Hurtado A, Holmes KA, …, Ali S, Carroll JS
Nature 2008 Nov 12 [abstract on PubMed] [related articles] [full text]
Selected by | Christopher Ormandy with Heather Lee
Evaluated 26 Nov 2008

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F1000 Factor 3.0

Hypothesis
 Genomic actions of 1,25-dihydroxyvitamin D3 on insulin receptor gene expression, insulin receptor number and insulin activity in the kidney, liver and adipose tissue of streptozotocin-induced diabetic rats.
Calle C, Maestro B, García-Arencibia M
BMC Mol Biol 2008 9:65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carolyn Ecelbarger
Evaluated 25 Nov 2008

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F1000 Factor 6.0

Hypothesis
New Finding
 Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer.
Locke JA, Guns ES, …, Gleave ME, Nelson CC
Cancer Res 2008 Aug 1 68(15):6407-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alvin Matsumoto
Evaluated 21 Nov 2008

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F1000 Factor 6.0

New Finding
 Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma.
Montero J, Morales A, …, Colell A, Fernández-Checa JC
Cancer Res 2008 Jul 1 68(13):5246-56 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Andrews
Evaluated 19 Nov 2008

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F1000 Factor 6.0

Hypothesis
New Finding
 Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines.
Anagnostou SH, Shepherd PR
Biochem J 2008 Dec 1 416(2):211-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alex Toker
Evaluated 18 Nov 2008

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F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
Novel Drug Target
 Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal.
Surget A, Saxe M, …, Hen R, Belzung C
Biol Psychiatry 2008 Aug 15 64(4):293-301 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Esther Sternberg with Marni Silverman
Evaluated 17 Nov 2008

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F1000 Factor 3.0

New Finding
 Testosterone for low libido in postmenopausal women not taking estrogen.
Davis SR, Moreau M, …, Studd J, APHRODITE Study Team
N Engl J Med 2008 Nov 6 359(19):2005-17 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Amory
Evaluated 17 Nov 2008

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F1000 Factor 6.0

Hypothesis
New Finding
 Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.
Song B, Scheuner D, …, Pennathur S, Kaufman RJ
J Clin Invest 2008 Oct 118(10):3378-89 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Raghavendra Mirmira
Evaluated 11 Nov 2008


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