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Browse > Pharmacology & Drug Discovery > Drug Discovery & Design
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Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Novel Drug Target
 Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway.
Park KK, Liu K, …, Sahin M, He Z
Science 2008 Nov 7 322(5903):963-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Vance Lemmon with Jessica K Lerch-Haner
Evaluated 28 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
New Finding
Novel Drug Target
 Distinct regions of prefrontal cortex mediate resistance and vulnerability to depression.
Koenigs M, Huey ED, …, Tranel D, Grafman J
J Neurosci 2008 Nov 19 28(47):12341-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Rinaman
Evaluated 28 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Nitroglycerin-induced S-nitrosylation and desensitization of soluble guanylyl cyclase contribute to nitrate tolerance.
Sayed N, Kim DD, …, Durán WN, Beuve A
Circ Res 2008 Sep 12 103(6):606-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Frenneaux with Julian O. M. Ormerod
Evaluated 28 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Novel Drug Target
 Targeting Inactive Enzyme Conformation: Aryl Diketoacid Derivatives as a New Class of PTP1B Inhibitors.
Liu S, Zeng LF, …, Long YQ, Zhang ZY
J Am Chem Soc 2008 Nov 14 0 [abstract on PubMed] [related articles] [full text]
Selected by | Amy Barrios
Evaluated 28 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase.
Yang G, Wu L, …, Snyder SH, Wang R
Science 2008 Oct 24 322(5901):587-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Robertson
Evaluated 27 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Immune evasion of Enterococcus faecalis by an extracellular gelatinase that cleaves C3 and iC3b.
Park SY, Shin YP, …, Seo SJ, Lee IH
J Immunol 2008 Nov 1 181(9):6328-36 [abstract on PubMed] [related articles] [order article]
Selected by | Emmanuelle Caron
Evaluated 26 Nov 2008

Exceptional
F1000 Factor 9.0

New Finding
Novel Drug Target
 Deconstructing voltage sensor function and pharmacology in sodium channels.
Bosmans F, Martin-Eauclaire MF, Swartz KJ
Nature 2008 Nov 13 456(7219):202-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 26 Nov 2008

Exceptional
F1000 Factor 9.0

New Finding
Tech Advance
 Structure of the intact PPAR-gamma-RXR-alpha nuclear receptor complex on DNA.
Chandra V, Huang P, …, Burris TP, Rastinejad F
Nature 2008 Oct 29 350-356 [abstract on PubMed] [related articles] [full text]
Selected by | Paul Webb
Evaluated 26 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen.
Hurtado A, Holmes KA, …, Ali S, Carroll JS
Nature 2008 Nov 12 [abstract on PubMed] [related articles] [full text]
Selected by | Christopher Ormandy with Heather Lee
Evaluated 26 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Straightforward and reversible photoregulation of hybridization by using a photochromic nucleoside.
Ogasawara S, Maeda M
Angew Chem Int Ed Engl 2008 47(46):8839-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andreas Marx
Evaluated 25 Nov 2008


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